Titration of Positive End-expiratory Pressure: Comparison Between Manual Thoracic or Abdominal Compression and Electrical Impedance Tomography

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentre Hospitalier Saint Joseph Saint Luc de Lyon

About this trial

Patients with acute respiratory distress syndrome are placed on mechanical ventilation, and the adjustment of ventilator parameters is an important step in their care, in particular positive expiratory pressure, applied at the end of breathing.

The goal of this study is to learn if continuous anterior chest compression works as well as electrical impedance tomography for positive expiratory pressure titration.

Researchers will compare the two methods for each patient, in a randomly determined order : continuous anterior chest compression and electrical impedance tomography.

Participants will :

* have a pep titration with both techniques * be included in the study for 28 days

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Moderate to severe ARDS according to the Berlin criteria

Patient receiving sedation and continuous curarization

Free and informed consent from the patient or their loved one

Disqualifiers

ECMO

Pneumothorax

Chest trauma in the last 3 months

Uncontrolled shock (noradrenaline > 5 mg/h)

Trial design

Design model

Single group

Treatments tested in this trial

  • PEEP titrations

    Other intervention

    Assessment of ideal PEEP using electrical impedance tomography will be performed. The evaluation of PEEP using the thorax compression maneuver method will be carried out. A blood sample (the "blood gases") will be taken at the ideal PEEP determined by electrical impedance tomography and at the ideal PEEP determined by the manual chest compression maneuver.

Treatment groups

30 Participants
are divided into 1 treatment group
Group A: PEEP titrationsOther 1 intervention

Trial outcomes

Primary outcomes

1

PEPCTAC

PEPCTAC (unit : cmH2O)

Time frame
Day 0
2

PEPCAC

PEPCAC (unit : cmH2O)

Time frame
Day 0
3

PEPEIT

PEPEIT (unit : cmH2O)

Time frame
Day 0

Secondary outcomes

1

Percentage of collapse at PEPCTAC

Percentage of collapse at PEPCTAC

Time frame
Day 0
2

Percentage of collapse at PEPCAC

Percentage of collapse PEPCAC

Time frame
Day 0
3

Percentage of collapse at PEPEIT

Percentage of collapse at PEPEIT

Time frame
Day 0
4

Compare respiratory mechanics for PEPCTAC and PEPCAC and PEPEIT

Respiratory mechanics at PEPCTAC and PEPCAC ans PEPEIT : peak and plateau pressure, driving pressure, respiratory system compliance, pulmonary and parietal compliance, respiratory system resistance, end-expiratory transpulmonary pressure, stress index at each PEEP level

Time frame
Day 0

Other outcomes

Sponsors and contacts

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