Health TrialsbyHealthPanel

TMS-based Assessment of Mental Training Effects on Motor Learning in Healthy Participants

ConditionMotor Learning
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorInstitut National de la Santé Et de la Recherche Médicale, France

About this trial

The general purpose of this research project is to analyze the specific role of motor imagery on motor learning, assessed through corticospinal excitability measurements and behavioral data collection. This project is based on four sequences. For Sequence 1, the main objective is to examine the effect of mental training on movement speed and accuracy in a manual motor sequence task, as well as the influence of sensory feedback in immediate post-test (i.e., execution of a similar, but not identical, manual motor sequence, other manual tasks) on performance in delayed post-test. The secondary objective will be to examine corticospinal changes (i.e., amplitude of motor evoked potentials) induced by mental training, by measuring the amplitude of motor evoked potentials before and after mental training. For Sequence 2, the main objective is to examine the impact of a motor disturbance induced by a robotic arm at different intervals during the motor imagery process. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training as a function of the applied perturbations, before and after perturbation. For Sequence 3, the main objective will be to examine the influence of neuroplasticity on the quality of mental training. More specifically, the investigators will study the links between brain plasticity and motor learning through mental training. The secondary objective will be to examine the corticospinal changes (i.e. amplitude of evoked motor potentials) induced by mental training at different levels of the neuromuscular system (cortical, cervicomedullar, peripheral) after a training period. For Sequence 4, the main objective will be to examine the effect of short-term arm-immobilization of on the retention of motor learning induced by mental training. The secondary objective will be to examine the corticospinal changes (i.e., amplitude of motor evoked potentials) induced by of short-term arm-immobilization, or by transcranial direct current stimulation (tDCS), on motor learning. The results of this fundamental research project will allow a better understanding of neurophysiological and behavioral mechanisms that underlie motor learning through motor imagery. The results will allow to efficiently consider inter-individual specificities and will thus open up to clinical research perspectives, towards the establishment of adapted motor rehabilitation protocols.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female between 18 and 60 years old

Having given written informed consent

Affiliated to a social security scheme

Disqualifiers

History of psychiatric illness (declarative)

Person under guardianship, curatorship, safeguard of justice

Neurological problem that could bias the results of the study (declarative)

Personal or family history of epilepsy

Trial design

Design model

Factorial

Treatments tested in this trial

  • Transcranial magnetic stimulation

    Device

    Magnetic stimulation of the cortex

  • Peripheral Nerve Stimulation

    Device

    Electric stimulation of the nerves

  • Transcranial direct current stimulation

    Device

    Electric stimulation of the cortex

  • Paired Associative Stimulation

    Device

    Combined magnetic and electric stimulation of cortex and nerve, respectively

  • Wrist

    Device

    Short-term immobilization of the arm

  • Robotic arm

    Device

    External perturbation of force field induced by robotic arm

  • Cervicomedullar stimulation

    Device

    Electric stimulation of the muscle

  • Physical training

    Other intervention

    Training to perform the task by actually doing the task

  • Mental training

    Other intervention

    Training to perform the task by imaging doing the task

Treatment groups

556 Participants
are divided into 28 treatment groups

28

Treatment groups

See each treatment group below.

Group A: Sequence 1 - Training with same task - Long follow-upExperimental treatment 2 interventions
Group B: Sequence 1 - Training with same task - Short follow-upExperimental treatment 2 interventions
Group C: Sequence 1 - Training with different tasks - Long follow-upExperimental treatment 2 interventions
Group D: Sequence 1 - Training with different tasks - Short follow-upExperimental treatment 2 interventions
Group E: Sequence 1 - Training with muscle contractions - Long follow-upExperimental treatment 2 interventions
Group F: Sequence 1 - Training with muscle contractions - Short follow-upExperimental treatment 2 interventions
Group G: Sequence 1 - ControlActive comparator 1 intervention
Group H: Sequence 2 - Physical training with perturbation during preparation - Long follow-upActive comparator 3 interventions
Group I: Sequence 2 - Physical training with perturbation during preparation - Short follow-upActive comparator 3 interventions
Group J: Sequence 2 - Physical training with perturbation after preparation - Long follow-upActive comparator 3 interventions
Group K: Sequence 2 - Physical training with perturbation after preparation - Short follow-upActive comparator 3 interventions
Group L: Sequence 2 - Mental training with perturbation during preparation - Long follow-upExperimental treatment 3 interventions
Group M: Sequence 2 - Mental training with perturbation during preparation - Short follow-upExperimental treatment 3 interventions
Group N: Sequence 2 - Mental training with perturbation after preparation - Long follow-upExperimental treatment 3 interventions
Group O: Sequence 2 - Mental training with perturbation after preparation - Short follow-upExperimental treatment 3 interventions
Group P: Sequence 3 - Training (same task) - Long follow-upExperimental treatment 5 interventions
Group Q: Sequence 3 - Training (same task) - Short follow-upExperimental treatment 5 interventions
Group R: Sequence 3 - Training (different task) - Long follow-upExperimental treatment 5 interventions
Group S: Sequence 3 - Training (different task) - Short follow-upExperimental treatment 5 interventions
Group T: Sequence 3 - Control 1Active comparator 4 interventions
Group U: Sequence 3 - Control 2Active comparator 4 interventions
Group V: Sequence 4 - Immobilization - Short follow-upExperimental treatment 3 interventions
Group W: Sequence 4 - Immobilization - Long follow-upExperimental treatment 3 interventions
Group X: Sequence 4 - Cathodal - Short follow-upExperimental treatment 3 interventions
Group Y: Sequence 4 - Cathodal - Long follow-upExperimental treatment 3 interventions
Group Z: Sequence 4 - Anodal - Short follow-upExperimental treatment 3 interventions
Group [: Sequence 4 - Anodal - Long follow-upExperimental treatment 3 interventions
Group \: Sequence 4 - ControlSham comparator 2 interventions

Trial outcomes

Primary outcomes

1

Evolution of movement speed - Sequence 1

The duration of performed movement sequences

Time frame
Each day in Sequence 1 (Sequence 1 is 11 days)
2

Evolution of movement accuracy - Sequence 1

The accuracy of performed movement sequences (i.e., the correspondence between the performed finger motor sequences and the requested finger motor sequence).

Time frame
Each day in Sequence 1 (Sequence 1 is 11 days)
3

Evolution of trajectory error - Sequence 2

The area under the curve of hand's trajectory according to the straight line joining the starting target and the final target.

Time frame
Each day in Sequence 2 (Sequence 1 is 10 days)
4

Evolution of maximal deviation - Sequence 2

The maximal perpendicular distance between the position of the hand and the straight line joining the starting target and the final target

Time frame
Each day in Sequence 2 (Sequence 1 is 10 days)

Secondary outcomes

1

Evolution of motor evoked potentials amplitude - Sequence 1

Peak-to-peak amplitude of motor evoked potentials

Time frame
Day 1, 5, 6, 10 and 11 in Sequence 1 (Sequence 1 is 11 days).
2

Evolution of motor evoked potentials amplitude - Sequence 2

Peak-to-peak amplitude of motor evoked potentials

Time frame
Each day in Sequence 2 (Sequence 2 is 10 days)
3

Evolution of motor evoked potentials amplitude - Sequence 3

Peak-to-peak amplitude of motor evoked potentials

Time frame
Day 1, 5, 6, 10 and 11 in Sequence 3 (Sequence 1 is 11 days)
4

Evolution of motor evoked potentials amplitude - Sequence 4

Peak-to-peak amplitude of motor evoked potentials

Time frame
Days 1, 5, and 6 in Sequence 4 (Sequence 4 is 6 days)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Institut National de la Santé Et de la Recherche Médicale, France

Lead sponsor

Source ClinicalTrials.gov
Apply now