The aim of this project is to compare the ovarian hormone levels 7 days after ovulation and progesterone:oestradiol ratios between PMDD individuals and a control cohort (case control study).
Aged 18-45 years old (adults but less than the typical perimenopausal age so there is not added bias/variable)
Regular menstrual cycles (21-35 days for the last 3 months)
Willing and able to complete a questionnaire (no new clinical diagnosis given)
Use home urine LH test strips to detect ovulation
Current use or use in the last 3 months of hormonal contraception such as the combined oral contraceptive pill, the progestogen only pill, the implant, the injection, hormonal coil (Mirena, Kyleena) or patch/ring.
Current use or use in the last 3 months of any hormone replacement therapy (e.g. combined oestrogen and progesterone, oestrogen and Mirena coil combination, oestrogen alone if had a hysterectomy, or progesterone alone) or GnRH analogues use
On a selective serotonin reuptake inhibitor (SSRI) with a recent initiation or dose change within the last 3 months
Pregnant, breastfeeding or within 3 months post partum
adults of reproductive age who experience menstrual cycles and have a diagnosis of, or symptoms consistent with, Premenstrual Dysphoric Disorder (PMDD) or a control population
Case-control
Prospective
Not listed
blood level
progesterone
blood level
oestrogen
blood test
progesterone to oestrogen level
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