This project proposes to elucidate the functional impact of T cells in cancer progression and treatment through a comprehensive TCR profiling study and a longitudinal cohort study in patients with advanced epithelial ovarian cancer. Our findings aim to provide clinical insights for monitoring treatment response in a non-invasive way and demonstrate the association of TCR diversity with clinical outcomes and the potential role of TCR profiling in cancer prognosis.
Newly diagnosed patients with advanced EOC, 18-75 years of age: including patients with preoperative assessment of stage III-IV EOC, who underwent initial tumour cytoreduction and 6-8 courses of postoperative chemotherapy with paclitaxel + carboplatin/docetaxel + carboplatin;
Eastern Cooperative Oncology Group (ECOG) physical strength status (PS) score of 0 or 1;
Cooperation in the treatment process by providing clinicopathological data and imaging data required for the study process;
Cooperate with follow-up visits and collection of node blood for clinical efficacy assessment, and agree to use the test data for subsequent research and product development.
Neoadjuvant chemotherapy patients;
Splenectomy patients;
Patients with contraindications to radiotherapy;
Any other patients who, in the judgement of the investigator, may have poor compliance with the procedures and requirements of the study;
advanced EOC
Case-control
Prospective
Not listed
Analysis of TCR genealogy data
1. Analysis of TCRα and TCRβ profile profiles in advanced EOC patients before initial treatment; 2. Analysis of differences in diversity of TCRα and TCRβ profiles in advanced EOC patients before treatment, after completion of treatment and at relapse; 3. Analysis of longitudinal TCR profiles revealing the stability and individual specificity of the immune profiles; 4. correlation of TCRα and TCRβ profiling diversity with levels of tumour markers (ca125, ca199, CEA, HE-4) and imaging findings under continuous monitoring to explore their value in monitoring tumour treatment response 5. Differential analysis of dynamic changes in TCRα profile and TCRβ profile in correlation with patients' clinical outcomes
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