Total Infectome Characterization of Eye Infections
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorShanghai General Hospital, Shanghai Jiao Tong University School of Medicine
About this trial
Multiple pathogens can cause eye infection. In recent years, emerging and resurging viral infections represent an important public health problem. Many emerging viruses cause infectious diseases involving ophthalmic manifestations, including Mpox virus, Zika, Ebola, and SARS-CoV-2. Broad and unbiased pathogen surveillance is essential, so we design this unbiased metagenomic sequencing based study to investigate the total infectome of eye infections. The study is historical and prospective in design.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with a clinical diagnosis of one or more types of eye infections (including acute conjunctivitis, keratitis, uveitis, and endophthalmitis).
Biological samples has been collected for clinical microbiological examination, or consented to participate in this study.
Disqualifiers
None
Trial population
Patients diagnosed with one or more types of eye infections (including acute conjunctivitis, keratitis, uveitis, and endophthalmitis).
Trial design
Design model
Case-only
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
200 Participants
are grouped into 1 trial groupGroup A: Eye infections cohort
Trial outcomes
Primary outcomes
1
The pathogen profile
The bacteria, fungi, viruses, and parasites identified through metagenomic techniques in ocular samples.
Time frame
through study completion, an average of 2 yearSecondary outcomes
1
Microbial abundance
The pathogen abundance is measure by the RPKM (i.e. Reads Per Million divided by the length of the reference genome, measured in kilobases).
Time frame
through study completion, an average of 2 yearSponsors and contacts
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Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Lead sponsor
Shanghai Fourth People's Hospital Tongji University
Collaborator
The Central Hospital of Huanggang
Collaborator
Source ClinicalTrials.gov