This study explores the potential of transcranial ultrasound stimulation (TUS) as an innovative therapeutic approach for individuals with Alcohol Use Disorder. By targeting specific brain regions associated with compulsive behaviors and reward dysfunction, the researchers aim to assess the safety and efficacy of TUS in reducing symptoms and enhancing cognitive flexibility.
Male or female, aged 21-55 years, and fluent English speaking.
Participants score ≥ 20 on the AUDIT.
Participant is willing and able to give informed consent for participation in the trial.
Participant is willing to comply with all trial requirements and committed to participating in all six testing sessions.
serious head trauma or brain surgery
(first-degree relatives with) epilepsy, convulsion, or seizure
diagnosis of a neurological or psychiatric disorder (other than AUD)
adverse reactions to non-invasive brain stimulation
Single group
low intensity transcranial focused ultrasound stimulation (TUS)
DeviceLow-intensity transcranial focused ultrasound (TUS) provides an energy source with millimeter resolution that can be focused anywhere in the brain safely and effectively for non-invasive and transient neuromodulation. TUS is an important advance and of great significance for brain-mapping efforts, diagnostics, and therapies in neuroscience and particularly promising for addiction therapy as it provides unprecedented non-surgical access to the brain regardless of depth. Low intensities of focused ultrasound (TUS) are used so that tissue damage does not occur, but neural activity can be modulated by mechanical effects.
Incidence of Treatment-Emergent Adverse Events
number of adverse events
Change in AUD symptoms
numerical AUD symptoms rating scale and Alcohol Consumptions
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