Tracing Brain Tumors Through Deep Time

ConditionsBrain Tumor Oncology

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

AgeNot listed

SponsorTata Memorial Centre

About this trial

Brain tumors involve different age groups with a wide range of tumor types involving different anatomical compartments of the brain. The evolution of the brain in vertebrates, including the most recent homo species (including humans), has occurred through increasing structural complexity in more evolved species. In the retrospective study, we will investigate the location of the tumors and different structural aspects of skull anatomy in patients with brain tumors. The information will be compared with the anatomical evolution of the brain and skull in vertebrates to look for possible associations, which can provide insights into evolutionary biology.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

CT/ MRI is not available before cranial radiotherapy

Artifacts causing distortion of skull (bony) anatomy

Trial population

Patients with diagnosis of primary brain tumors will be screened for the study. Approximately 500-600 patients are treated annually with radiation in our center with available CT data for radiation planning, and another 100-200 patients having pre-operative or post-operative scans. For the above-mentioned time period, data is expected to be available from approximately 10,000 patients, which will be the upper limit of sample size for the current study.

Trial design

Design model

Case-only

Time perspective

Retrospective

Treatments tested in this trial

Imaging with CT and MRI
Diagnostic test
Quantitative and anthropometric analysis of brain and skull strutcure of imaging (CT/ MRI) undertaken as part of diagnosis or treatment for patients with brain tumor

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

Age-based density maps of brain tumor location

Tumor location for different age groups will be analyzed using proportions (percentage of tumor area in normal brain).

Time frame

36 months

Secondary outcomes

Anthropometric analysis of skulls

Cranial index (maximum cranial width/ maximum cranial length x100) will be analyzed using descriptive statistics (mean, median, range, standard deviation).

Time frame

36 months

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tata Memorial Centre

Lead sponsor

Indian Statistical Institute, Kolkata

Collaborator

Source ClinicalTrials.gov

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