Tracking a Tactile Signal Along the Nervous System
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorVirginia Polytechnic Institute and State University
About this trial
Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
participants who are neurotypical will be a similar age to the participants with stroke
participants who are neurotypical will have no musculoskeletal and neurological conditions
participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)
participants with stroke will be in the chronic phase (>1 year from stroke onset)
Disqualifiers
minors
pregnant women
prisoners
adults not capable of consenting on their own behalf.
Trial design
Design model
Single group
Treatments tested in this trial
Tactile stimulation
BehavioralTactile stimuli of differing magnitudes will be applied
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: Stimulus magnitudeExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Conscious detection threshold
The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N.
Time frame
30 minutes during the first session of a one session protocolSecondary outcomes
1
Brain activation
The magnitude and regions of brain activated in response to differing levels of force stimuli will be captured using fMRI. The % signal change in the brain will be used to define the brain activation in response to each force stimulus level.
Time frame
60 minutes during the first session of a one session protocolOther outcomes
1
Peripheral nerve function
Electrotactile stimuli will be applied to a finger, with the current (A) changing in magnitude. We will measure the level to which the peripheral nerve is activated using surface electrodes, which identify changes in voltage along the nerve.
Time frame
30 minutes during the first session of a one session evaluation protocolSponsors and contacts
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Source ClinicalTrials.gov