This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and obsessive-compulsive disorder, based on family history or subthreshold emotional or behavioral symptoms. Participants will be followed for two years. Clinical assessments, questionnaires, EEG, biological samples, and MRI will be collected at scheduled intervals. The study aims to identify factors associated with the onset and progression of these disorders and support early risk identification.
Aged 7-17 years at enrollment.
Meeting at least one of the following conditions: Having at least one first-degree relative with a depressive disorder, anxiety disorder, or obsessive-compulsive disorder; or exhibiting clinically relevant but subthreshold depressive, anxiety, obsessive-compulsive, or repetitive behavioral symptoms.
Not meeting the full diagnostic criteria for a depressive disorder, anxiety disorder, or obsessive-compulsive disorder at baseline, as assessed using the K-SADS-PL.
Willing and able to participate in the scheduled assessments and follow-up visits.
A current or previous diagnosis of a depressive disorder, anxiety disorder, or obsessive-compulsive disorder.
A severe psychiatric condition requiring immediate clinical intervention, including acute suicide risk, a psychotic disorder, or a bipolar disorder.
A major neurological disorder, severe head injury, or serious or unstable medical condition that may interfere with study participation.
Intellectual or cognitive impairment that prevents the participant from understanding or completing the study assessments.
Shanghai Mental Health Center
Lead sponsor
Fudan University
Collaborator
Southeast University, China
Collaborator