Background:
\- Tuberculosis (TB) is an infectious disease that affects numerous people worldwide. Researchers are interested in actively recruiting individuals with TB for research and treatment studies.
Objectives:
\- To collect blood and other samples to study the natural history of tuberculosis.
Eligibility:
\- Individuals 2 years of age and older who have either active or latent tuberculosis.
Design:
* Latent TB patients: Participants will have a single study visit with a physical examination and medical history, and will provide blood samples for testing. * Active TB patients: Participants will have an initial visit with a physical examination and medical history, and will provide blood samples for testing. Participants will also provide sputum samples if required, and may have an optional skin punch biopsy to collect a sample of skin tissue for study. * Treatment for active TB will be provided as part of this protocol. * Active TB participants may be asked to return for study visits every 1-2 months while receiving treatment....
Have or are suspected to have TB infection.
Are aged 2 years or older.
Have a primary care physician, infectious diseases physician, pulmonologist, or TB specialist outside of the NIH who can provide care of his or her TB infection outside the NIH, provide directly observed therapy (DOT) if necessary, and monitor for side effects and toxicity of TB medications.
Are willing to consent to storage of specimens for future research.
Are incarcerated.
Have been ordered by a court to take TB medications.
Are unwilling or unable to comply with prescribed therapy.
Are pregnant.
Patients will be referred by their physicians for study participation. In many cases, participants will be referred by physicians at their local health department tuberculosis clinics (where they often receive DOT for TB treatment). Family members may be recruited through requests made by the index case that family members contact study personnel for participation. A patient can be referred at any time point while he or she is receiving active treatment for tuberculosis. Male and female patients will be accepted without preference. Patients age 2 and older are eligible; however, severe infections may require highly specialized pediatric teams and institutions. Some referrals of pediatric cases will not be able to be handled appropriately at the NIH and may be deemed ineligible for admission, as determined by the Principal Investigator (PI). NIH employees and members of their immediate families may participate in this protocol.
Cohort
Prospective
Not listed
Increase in the number of TB patients being actively followed at the NIH CC to provide information on TB patients with DS and drug-resistant disease for hypothesis generation and hands-on experience in the management of TB
increased number of TB patients being actively followed at the NIH CC
Determination of subsets of lymphoid populations during various points in the treatment of TB
subsets of lymphoid populations during various points in treatment of TB
Description of whole genome sequences and their possible relationship to TB infection
possible relationship of whole genome sequences to TB infection
Collection of MTB specimens for studies of the organism and its pathogenesis
collection of MTB specimens
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