The goal of this clinical trial is to learn if transcranial alternating current stimulation can shorten the duration of delirium in intensive care setting. The main question it aims to answer:
* Is it possible to shorten the duration of delirium with transcranial alternating current stimulation?
Researchers will compare experimental treatment to sham.
Participants will receive experimental or sham treatment on maximum of two days depending on their delirium status. Duration of delirium is recorded and reported as "days alive and free of delirium".
Delirium in intensive care and duration of delirium for more than 24 hours. Delirium is defined as 4 or more points on ICDSC and -1 or more points on RASS.
Under 18 years of age, pregnancy, delirium tremens, epilepsy or history of seizures any time before first trial intervention, active psychotic disease, infection of central nervous system, acute intoxication, traumatic brain injury, stroke, intracranial bleeding and implanted electronic devices.
Parallel
Transcranial alternating current stimulation (TACS)
DeviceTranscranial alternating sinusoidal current at frequency of 40 Hz applied for 60 min through a pair of saline-soaked surface sponge electrodes.
Sham TACS
DeviceSham treatment with few seconds of actual electrical current and same electrode configuration
Days alive and free of delirium or coma
Days alive and free of delirium or coma
Biomarker profile
Concentrations of neurofilament light (nfl), glial fibrillary acid (gfap) and plasma tau (ptau) on days 0, 2 and 4
EEG changes
EEG Spectral power
CERAD
CERAD test (Consortium to Establish a Registry for Alzheimer's Disease)
TMT test A
Trail Making Test A
Click on the lead sponsor to view all of their trials.
