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Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke

ConditionsStrokeAphasia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorMedical College of Wisconsin

About this trial

This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosed with left hemisphere stroke/aphasia

Consent date >= 1 month after stroke onset

Fluent in English

18 years of age or older

Disqualifiers

Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing

Presence of major untreated or unstable psychiatric disease

A chronic medical condition that is not treated or is unstable

The presence of cardiac stimulators or pacemakers

Trial design

Design model

Parallel

Treatments tested in this trial

  • HD-tACS

    Device

    High definition tACS will be applied during speech therapy.

  • Sham HD-tACS

    Device

    Sham high definition tACS will be applied during speech therapy.

Treatment groups

120 Participants
are divided into 2 treatment groups
Group A: High Definition tACS with Short-term Memory Focused Speech TherapyExperimental treatment 1 intervention
Group B: Sham-High Definition tACS with Short-term Memory Focused Speech TherapySham comparator 1 intervention

Trial outcomes

Primary outcomes

1

Accuracy on a phonological STM task

Accuracy changes in a delayed sample-to-match task assessing phonological STM after tACS.

Time frame
Upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post
2

fMRI measures of language network activation after tACS

Activation in the language network regions involved in phonological STM will be assessed before and after tACS

Time frame
Upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post

Secondary outcomes

1

Functional Communication Outcome

Improvements in using language in daily life or functional communication as assessed by patient reported measure of Communication Effectiveness Index (CETI)

Time frame
Upon the completion of therapy cycle (a cycle consists of 10 intervention days) and 10 weeks post

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medical College of Wisconsin

Lead sponsor

Source ClinicalTrials.gov
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