Transcranial Doppler, Optic Nerve Envelope Diameter and Quantitative Pupillometry Measurements

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier Universitaire de la Réunion

About this trial

Non-invasive neuromonitoring tools such as transcranial doppler, optic nerve envelope diameter measurement and quantitative pupillometry are routinely used in acute brain injured patients as part of multimodal neuromonitoring with the aim, among others, of detecting episodes of intracranial hypertension, each method allowing the study of one of the different pathophysiological mechanisms of its impact.

However, at present there is no data in the literature on the value of these non-invasive neuromonitoring tools in the management of patients undergoing controlled intracranial surgery.

The study aims to help the early detection of postoperative neurological deterioration.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Regulated intracranial surgery: scheduled > 48 hours

French-speaking patient

No opposition from the patient or a relative when the patient is unable to consent

Disqualifiers

Chronic subdural haematoma

Isolated cerebral endovascular procedure

Stereotactic biopsy

Scheduled ventriculoperitoneal shunt or isolated ventriculocisternostomy

Trial population

Patients undergoing planned neurosurgery

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Non-invasive neuromonitoring evaluation (transcranial doppler, optic nerve envelope diameter and quantitative pupillometry)

    Other intervention

    4 days Post-operation follow-up. Data will be gathered before the surgery and at regular times after the surgery until day 4

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Evolution of non-invasive neuromonitoring measures (using transcranial doppler)

This emasure will be performed bilaterally at the level of the first part of the middle cerebral artery, the values collected will be: * Systolic, mean and diastolic velocities; pulsatility index * Estimation of intracranial pressure

Time frame
From 1 hour before the surgery until Day 4 post-surgery
2

Evolution of non-invasive neuromonitoring measures (optic nerve envelope diameter)

The diameter of the optic nerve envelope will be collected bilaterally using an ultrasound machine

Time frame
From 1 hour before the surgery until Day 4 post-surgery
3

Evolution of non-invasive neuromonitoring measures (quantitative pupillometry)

The values collected will be : \- Size, quantification of the amplitude of variation to light, latency and speed of constriction of the pupil, presence or absence of anisocoria (defined by a difference \>1mm in size between the two pupils)

Time frame
From 1 hour before the surgery until Day 4 post-surgery

Secondary outcomes

Other outcomes

Sponsors and contacts

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