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Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

ConditionsAutism Spectrum DisorderAutismAsperger Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age12-45
SponsorStanford University

About this trial

Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of Autism Spectrum Disorder (ASD)

Meet criteria for Autism Spectrum Disorder (ASD) on clinical assessments (ADOS-2 or CARS if conducted remotely & ADI-R)

Aged between 12-45 years old

Have a reliable informant who can complete relevant questionnaires

Disqualifiers

Any contraindications for TMS e.g. history of seizures other than clear substance-induced/fever-induced seizures with neurologist note or normal clean EEG and no seizure in at least 12 months prior to enrollment.

Pregnancy.

Any current or past history of any physical condition which in the investigator's opinion might put the subject at risk or interfere with study results interpretation.

Active substance use (<1 week) or intoxication verified by toxicology screen--of cocaine, amphetamines, benzodiazepines.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Transcranial magnetic stimulation

    Device

    Non-invasive brain stimulation technique that is FDA-approved for the treatment of refractory depression, OCD and migraine.

Treatment groups

67 Participants
are divided into 2 treatment groups
Group A: Targeting insistence on samenessExperimental treatment 1 intervention
Group B: Targeting stereotyped motor behaviorsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Repetitive Behavior Scale-Revised (RBS-R)

44-item parent-report questionnaire to measure restricted and repetitive behavior in ASD. We predict that each TMS target will selectively reduce the subscale being targeted.

Time frame
Up to one month post-treatment

Secondary outcomes

1

Set-shifting performance (Dimensional Change Card Sort Test score)

The Dimensional Change Card Sort Test one of the cognitive measures from the NIH toolbox. These measures are administered on an iPad. The test takes 4 minutes to complete.

Time frame
Baseline & immediately after treatment

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Stanford University

Lead sponsor

Source ClinicalTrials.gov
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