Health TrialsbyHealthPanel

Treatment of Borderline Personality Disorder With rTMS

ConditionsBorderline Personality DisorderBorderline PersonalityBPD - Borderline Personality Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of California, Los Angeles

About this trial

This project studies the effectiveness of brain stimulation on borderline personality disorder (BPD) symptoms. This study is blinded, randomized and will enroll up to 30 participants.

Participant will be consented for the study remotely via a secure internet platform called Zoom.

Participants will undergo up to 2 MRI scans, 2 brain wave recording sessions and up to 30 brain stimulation treatments, and complete symptom assessments and cognitive behavioral tasks on a computer. Participation requires minimum of 17 in person visits over the course of 2.5 months.

Participants are randomly assigned active or sham brain stimulation. Participants who received sham brain stimulation have the option to receive additional 15 active brain stimulation session.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age of 18-65

DSM-5 Diagnosis of BPD based upon a psychiatric evaluation and ZAN-BPD

Fluent English speaker

Signed informed consent

Disqualifiers

None

Trial design

Design model

Crossover

Treatments tested in this trial

  • Transcranial Magnetic Stimulation (TMS)

    Device

    Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. Using pulsed magnetic fields, transcranial magnetic stimulation therapy stimulates the part of the brain thought to be involved with mood regulation. These magnetic fields do not directly affect the whole brain; they only reach about 2-3 centimeters into the brain directly beneath the treatment coil.As these magnetic fields move into the brain, they produce very small electrical currents. These electrical currents activate cells within the brain, causing them to rewire, a process called neuroplasticity.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: ActiveExperimental treatment 1 intervention
Group B: Sham- followed by Active treatmentExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Borderline Symptom List 23 (BSL-23)

Borderline Symptom List 23 (BSL-23)

Time frame
Baseline (Day 1) and Post treatment (Day 17)
2

Clinical Global Impression for Borderline Personality Disorder (CGI-BPD)

Clinical Global Impression for Borderline Personality Disorder (CGI-BPD)

Time frame
Baseline (Day 1) and Post treatment (Day 17)
3

Difficulties in Emotion Regulation Scale (DERS)

Difficulties in Emotion Regulation Scale (DERS)

Time frame
Baseline (Day 1) and Post treatment (Day 17)

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of California, Los Angeles

Lead sponsor

Source ClinicalTrials.gov
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