Radiosurgery is the use of a focal high dose of radiation therapy to ablate or kill a tumor. This trial will enroll patients with brain metastases 4 cm or less in greatest diameter and will compare 0mm margin to a 2mm margin for treatment.
Stated willingness to comply with all study procedures and availability for the duration of the study
Male or female, aged 19 and older
Brain metastases diagnosis not requiring retreatment to the same tumor
For females of reproductive potential should undergo pregnancy testing as per UAB Radiation Oncology standard policies
Current use of cytotoxic chemotherapy within 3 days of treatment. There are no restrictions on the use of immunotherapy during treatment. TKIs known to be radiation sensitizers such as BRAF should be held at least 24 hours prior to treatment.
Inability to have MRI imaging
Pregnancy
Treatment with another investigational drug 14 days of enrollment