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TRIO CTO (Taiwan Research Initiative on Coronary Total Occlusion)

ConditionChronic Total Occlusion (CTO)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-120
SponsorNational Taiwan University Hospital

About this trial

Coronary chronic total occlusions (CTO) present a significant challenge in the field of interventional cardiology. These complex lesions, characterized by complete blockage of a coronary artery for a prolonged duration, often require specialized techniques and strategies to achieve successful revascularization.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Over 20 years old

Chronic total occlusion confirmed by coronary angiography, and noted for more than 3 months

Disqualifiers

None

Trial population

1. Over 20 years old 2. Chronic total occlusion confirmed by coronary angiography, and noted for more than 3 months

Trial design

Design model

Case-control

Time perspective

Retrospective

Treatments tested in this trial

  • Percutaneous coronary intervention of coronary chronic total occlusion

    Procedure/Surgery

    Coronary CTO was identified by coronary angiography, and its revascularization was attempted by either antegrade, retrograde or both approach.

Treatment groups

5,000 Participants
are divided into 3 treatment groups
Group A: Successful CTO intervention1 intervention
Group B: Failed CTO intervention1 intervention
Group C: No CTO intervention0 interventions

Trial outcomes

Primary outcomes

1

Number of participants with technical success of CTO revascularization

Successful CTO recanalization with \<20% residual stenosis within the treated segment and restoration of Thrombolysis in Myocardial Infarction grade 3 antegrade flow, without side branch loss

Time frame
1 day
2

Number of participants with collateral channel tracking success

retrograde guidewire crossing the CC to reach the distal cap of CTO segment.

Time frame
1 day
3

Number of participants with major adverse cerebral cardiovascular events

Death, CV death, myocardial infarction, stroke, repeat revascularization

Time frame
5 years

Secondary outcomes

1

Number of participants with periprocedural myocardial infarction

Confirmed by

Time frame
1 day
2

Number of participants with periprocedural complications

Periprocedural myocardial infarction, vessel perforation, stroke, urgent or emergent revascularization

Time frame
1 day

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National Taiwan University Hospital

Lead sponsor

Chang Gung Memorial Hospital

Collaborator

Taipei Veterans General Hospital, Taiwan

Collaborator

Source ClinicalTrials.gov
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