Twins Born in Guangzhou
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 18
SponsorGuangzhou Women and Children's Medical Center
About this trial
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology. Data are collected regarding environmental, family and lifestyle exposures on twins from birth to 18 years old. Biological samples including blood and tissue samples are also collected from the twins and their parents.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Live twins delivered in Guangzhou Women and Children's Medical Center
Permanent residents or families intended to remain in Guangzhou with their children for no less than 3 years
Baseline information during pregnancy available
Disqualifiers
None
Trial population
Twins delivered in Guangzhou, China and their parents
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
No intervention
Other intervention
Treatment groups
1,000 Participants
are divided into 2 treatment groupsGroup A: Identical Twins1 intervention
Group B: Dizygotic Twins1 intervention
Trial outcomes
Primary outcomes
1
Neurodevelopment at early childhood
Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules.
Time frame
At age of 1 year old2
Intelligence quotient
Assessed using the Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition including 5 verbal and 3 performance subtests. Intelligence quotient ranges 40-160, in which under 70 is defined as mental retardation. The total score was calculated by an online system.
Time frame
At age of 6 years old3
Change of gene expression during childhood
DNA methylation, histone acetylation etc. assessed by analyses of blood samples
Time frame
Age at 1 year , 6 years, 12years and 18yearsSecondary outcomes
1
Change of intestinal flora during early childhood
Assessed by analyses of stool samples
Time frame
Age at 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years2
Changes of body composition and bone density during early childhood
Body composition and bone density are assessed using Dual Energy X-Ray Absorptiometry
Time frame
At birth, age of 6 weeks, 6 months, 1 year , 3 years,6 years, 12years and 18years3
Height in kilometer changes during childhood
Measured by nurses in clinic
Time frame
At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18year4
Weight in kilogram changes during childhood
Measured by nurses in clinic
Time frame
At birth, age of 6 weeks, 6 months, 1 year, 3 years,6 years, 12years and 18yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov