Two-channel IV-PCA With Dexmedetomidine
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age20+
SponsorKorea University Guro Hospital
About this trial
Dexmedetomidine was administered in the 'selector' channel and fentanyl in the 'basic \& bolus' channel of dual channel intravenous patient-controlled analgesia (IV-PCA) and the amount of opioid consumption was compared. In addition, intensity of pain, postoperative nausea/vomiting, and postoperative delirium was evaluated.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients who was scheduled for laparoscopic major abdominal surgery (Gastrectomy, Hepatectomy, Colectomy, Pancreatectomy) under general anesthesia
Aged ≥ 20 years old
Disqualifiers
Body mass index ≥35 kg/m2
American Society of Anesthesiologists physical status > 3
Severe cardiovascular disorder
Severe liver or renal dysfunction
Trial design
Design model
Parallel
Treatments tested in this trial
Dexmedetomidine
DrugDexmedetomidine 0.2mcg/kg/hr (2ml/hr) administration via continuous channel in the experimental group
Control
DrugNormal saline 2ml/hr administration via continuous channel in the experimental group
Treatment groups
110 Participants
are divided into 2 treatment groupsGroup A: Control groupActive comparator 1 intervention
Group B: Dexmedetomidine groupExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Fentanyl consumption during 24 hours
Cumulative consumption of fentanyl during 24 hours
Time frame
24 hours after surgerySecondary outcomes
1
Additional analgesic consumption at post-anesthesia care unit
Opioid, NSAID, or acetaminophen consumption
Time frame
1 hour after surgery2
Fentanyl consumption during 1,6,48 hours
Cumulative consumption of fentanyl during 1,6,48 hours
Time frame
1,6,24,48 hours after surgery3
Pain scores at 1,6,24,48 hours
11-pointed numerical rating scale pain score (0 \[no pain\]-10 \[Extreme pain\])
Time frame
1,6,24,48 hours after surgery4
Rescue analgesic consumption at 1,6,24,48 hours
Additional opioid, NSAID, or acetaminophen consumption
Time frame
1,6,24,48 hours after surgerySponsors and contacts
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Source ClinicalTrials.gov