About this trial
Induction of anesthesia by inhalation is the most common method of induction (70% in France) for young children admitted for non-emergency surgery. It has the advantage of not requiring an intravenous line.
Serious respiratory adverse events such as laryngospasm or bronchospasm remain common in young children during anesthesia induction (approximately 4%) and can reach up to 30% when mild respiratory adverse events (coughing, desaturation \< 95%, airway obstruction) are included.
Traditionally, inhalation induction is performed under spontaneous ventilation using the anesthesia ventilator circuit. However, modern ventilators offer the option of applying positive end-expiratory pressure (PEEP) and pressure support ventilation (PSV). Several physiological studies suggest that the use of PEEP + PSV during anesthesia may help maintain airway patency, minute ventilation, and functional residual capacity (FRC).
Our hypothesis is that administering PEEP + PSV at the time of induction may reduce the risk of respiratory complications.
The primary objective is to demonstrate that induction of anesthesia using PEP + PSV, compared with induction of anesthesia under spontaneous ventilation, reduces the risk of adverse respiratory events in children requiring general anesthesia with planned inhalational induction.
Eligibility criteria
Qualifiers
Child between 3 months and 6 years old
Without significant comorbidity (ASA 1 or 2)
Admitted for elective or emergency/urgent surgery under general anesthesia
With induction of anaesthesia by inhalation by sevoflurane on the machine circuit
Disqualifiers
Children with severe upper respiratory tract infection (severe moist cough, fever and lethargy, oxygen requirement) in the last 7 days requiring intravenous induction or postpone of the surgery
Thoracic surgery with selective control of intubation
Criteria for difficult intubation or known history of difficult intubation
Children with a contraindication to sevoflurane (ex: risk of malignant hyperthermia)
Trial design
Treatments tested in this trial
- Induction with PEEP (5 cmH2O) and PSV (2-12 cmH2O)
- Induction in spontaneous breathing