This study plans to find the most suitable lymph node cortex thickness and abnormal lymph node features to define suspicious lymph nodes. Then, ultrasound-guided core needle biopsy of axillary lymph nodes will be done, aiming to provide some guidance for the biopsy.
Age ≥18 years and <70 years;
Histologically confirmed primary breast cancer;
Underwent ultrasound examination to assess axillary lymph node metastasis status.
Presence of other malignancies (e.g., lymphoma, lung cancer, thyroid cancer, etc., with axillary metastasis);
Pregnant or lactating women;
Previous receipt of neoadjuvant radiotherapy or chemotherapy;
Lymph node metastasis status not confirmed by pathology, or time interval between ultrasound examination and pathological confirmation exceeding 6 weeks.
Consecutive patients newly diagnosed with primary breast cancer and assessed for axillary lymph node metastasis by ultrasound, prospectively enrolled from November 2025 to November 2026 across multiple hospitals.
Other
Prospective
Not listed
Maximum cortical thickness of the lymph node (mm)
The maximum thickness of the lymph node's cortical layer. Measured via conventional ultrasound examination of the lymph node's long-axis cross-section, perpendicular to the capsule surface, determining the maximum distance from the capsule to the corticomedullary junction.
Age
Age of participants at the time of initial diagnosis of primary breast cancer, reported in years.
Menstrual Status
Menstrual status at initial diagnosis of primary breast cancer, assessed by medical record review and categorized as premenopausal, perimenopausal, postmenopausal, or unknown.
Lymph node axial ratio
The ratio of the maximum longitudinal diameter to the maximum transverse diameter of the lymph node. The maximum longitudinal diameter and maximum transverse diameter of the lymph node are measured separately, and the axial ratio is obtained by dividing the measured longitudinal diameter value by the transverse diameter value.
Lymph node margin regularity
Categorized as either regular or irregular.
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The First Hospital of Jilin University
Lead sponsor
Siping Central People's Hospital
Collaborator
Baicheng Central Hospital
Collaborator
Jilin Central General Hospital
Collaborator
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