Ultrasound Guided External Oblique Intercostal Plane Block Versus Erector Spinae Block for Post Hepatectomy Pain

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorNational Cancer Institute, Egypt

About this trial

Management of acute post-operative pain has received keen attention in recent years with considerable concurrent advancement in the field.

The importance of effective pain relief has long been realised, and acute pain services (APS) are operational in majority of the hospitals in the developed world for decades.

Postoperative pain following abdominal surgery if severe enough may cause several side effects as "splinting, hypoventilation, atelectasis, immobility, hypercoagulability, thromboembolic events, vasoconstriction, tachycardia, increased systemic vascular resistance, dysrhythmias and cardiac ischemia in susceptible patients, insomnia, anxiety, feeling of helplessness".

Ultrasound-guided fascial plane blocks have been rapidly incorporated into regional anaesthesia practice in recent years as an alternative to neuraxial techniques and involve injection into a tissue plane to provide analgesia in various anatomic areas.

External oblique intercostal plane block (EOIPB) is a novel block, which has been described as an important modification of the fascial plane blocks that can consistently involve the upper lateral abdominal walls.

The erector spinae plane (ESP) block is a new regional aesthetic technique that can be used to provide analgesia for a variety of surgical procedures or to manage acute or chronic pain. The technique is relatively easy to perform on patients.

The ESPB involves injection of local anaesthetic in the erector spinae fascial plane, superficial to the tip of the transverse process of the vertebra and deep to the erector spinae muscle.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Cancer patients undergoing hepatectomy under general anaesthesia

Aged 18 years or older

ASA II & III

BMI >20kg/m2 and <35kg/m2

Disqualifiers

History of psychiatric disorders or history of major depression.

Major medical conditions (heart failure , chronic kidney disease ,patient on dialysis)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Ultrasound guided external oblique intercostal (EOI) plane block

    Procedure/Surgery

    Patient lies supine with their ipsilateral arm abducted. A 12-15 MHz linear transducer will be used. The proceduralist scans the chest wall while at the patient's ipsilateral shoulder. The probe is placed in a cephalad to caudad paramedian direction at the anterior axillary line, and the external oblique muscle (EOM) is identified at the level of ribs 6 \&7 in line with the xiphoid process. To confirm identification of the EOM, the probe is moved caudally following the EOM. At the subcostal level, the ultrasound probe is rotated 90° to see the convergence of the internal oblique \& transversus abdominus muscles. The probe is then moved back to the initial identification point. The EOI plane is identified deep to the external oblique and superficial to the 6th \& 7th ribs and their associated intercostal muscles. Local anaesthetic is injected subcutaneously \& a 16 G Tuohy needle is inserted caudally; the EOI plane is hydrodissected with saline, injecting 20 ml of 0.25% bupivacaine.

  • Ultrasound guided erector spinae block

    Procedure/Surgery

    The patient lies in lateral position, then spinous processes are palpated and marked directly on the skin by a dermographic pencil, and the correctness of the final marking is confirmed by sonographic inspection. A 21G, 50 mm needle isinserted with a cephalad-to-caudal direction into the posterior thoracic wall at the T5 level, to reach the respective transverse process. The proper needle tip positioning ischecked by ultrasound guidance with a 12.5 MHz linear probe (FUJIFILM Sonosite M-Turbo C Ultrasound System) the visualization of a linear fluid spread that distended the fascial plane between the erector spinae muscles group and the transverse process while injecting 2 mL of normal saline solution isconsidered confirmatory. Subsequently, 20 mL of local anaesthetic injected 0.25% bupivacaine

Treatment groups

52 Participants
are divided into 2 treatment groups
Group A: External Oblique Intercostal (EOI) Plane BlockActive comparator 1 intervention
Group B: Erector Spinae (ESP) BlockActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Pain scores using Visual analogue score

Pain scores using Visual analogue score (VAS) (0 mm = no pain to 10mm = worst pain imaginable) at predetermined time intervals (1,6, 12 and 24h) postoperative.

Time frame
24 hours after surgery

Secondary outcomes

1

Time of first rescue postoperative analgesia

The total 24-hour morphine consumption will be recorded for every patient post operative.

Time frame
First 24 hours post-operative
2

Total amount of fentanyl consumed intraoperative

the rescue analgesia will be administered intra-operative by fentanyl IV and the total fentanyl used will be recorded and compared between the groups

Time frame
Duration of the surgery
3

Total amount of morphine consumed postoperatively

The total 24-hour morphine consumption will be recorded for every patient post operative.

Time frame
First 24 hours post-operative
4

Post-operative morphine side effects in the post-operative period.

Postoperative nausea and vomiting (PONV), respiratory depression and/or sedation

Time frame
First 24 hours post-operative

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: