Ultrasound Guided Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) Versus Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-71
SponsorAin Shams University

About this trial

This study aims to compare the efficacy of using Ultrasound guided modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) versus quadratus lumborum block for postoperative analgesia in laparoscopic cholecystectomy under general anesthesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adult patients aging ≥ 21 years to ≤ 70 of both sexes.

Patients undergoing Laparoscopic cholecystectomy surgeries.

ASA physical status classes I - II.

Disqualifiers

Patient's refusal of procedure or participation in the study.

ASA classes III or above.

Coagulopathy and bleeding disorders.

Evidence of Local skin infections at site of injection.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA)

    Procedure/Surgery

    transversus abdominis, internal oblique, and external oblique muscles will be identified with a high-frequency (10 MHz) linear probe on the costochondral angle in the sagittal plane under ultrasound guidance at the 10th costal margin. A deep angle was given to the costochondral angle at the edge of the 10th costal margin with the probe in the sagittal direction to view the lower surface of the costal cartilage in the midline. A 22-G, 100-mm block needle will be inserted in the cranial direction using the in-plane technique and the needle tip will be moved to the posterior aspect of the 10th costal cartilage. It is noted that the needle tip never crossed the cranial edge of the 10th costal cartilage

  • Quadratus lumborum block

    Procedure/Surgery

    using ultrasound guidance (Sonosite turbo M, Bothell, Washington, USA) and a curved ultrasound probe (2.5-7.5 MHz). The probe will be placed in the mid-axillary line between the lower costal margin and the iliac crest in a transverse plane to view all abdominal layers. The probe will be moved towards the posterior axillary line, to reach a point where all three abdominal muscle layers merge to form aponeurosis. The aponeurosis will then be followed dorsally until the quadratus lumborum muscle is seen deep to transversalis fascia with its attachment to the transverse process of the L4 vertebral body. A 22 G, 100 mm, blunt, insulated nerve block needle will be inserted 1 cm medial to the probe and advanced using the in-plane technique with ultrasound real-time assessment. The injection site will be the junction of transversalis fascia and the anterolateral border of quadratus lumborum muscle

Treatment groups

52 Participants
are divided into 2 treatment groups
Group A: Modified thoracoabdominal nerve block through perichondrial approach (M-TAPA)Experimental treatment 1 intervention
Group B: Quadratus lumborum blockExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Time to first Rescue Analgesia

Is to measure the first time to resque analgesia postoperative (24 hours)

Time frame
24 hours postoperative

Secondary outcomes

1

The total requirements of rescue analgesia Meperidine (pethidine) over the first 24 hours postoperative

Time frame
24 hours postoperative
2

Heart rate

Time frame
at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively
3

Blood pressure

Time frame
at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively
4

Spo2 measuring

Time frame
at intervals of 0 (PACU), 1, 2, 4, 6, 12, 18 and 24 hours postoperatively

Other outcomes

Sponsors and contacts

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