Ultrasound-guided Thermal Ablation for Papillary Thyroid Carcinoma
ConditionPapillary Thyroid Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorChinese PLA General Hospital
About this trial
To evaluate long-term outcomes of ultrasound-guided thermal ablation for the treatment of papillary thyroid carcinoma
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
patients age between 18 and 80 year old, both sex
papillary thyroid carcinoma confirmed by core-needle biopsy or fine-needle aspiration
the largest diameter ≤2.0 cm
no clinical or imaging evidences of extrathyroidal extension, lymph node metastasis and distant metastasis on ultrasound, neck and chest CT
Disqualifiers
patients with convincing evidence of aggressive papillary thyroid carcinoma or other type of thyroid cancer by biopsy
history of neck radiation
coagulation disorder, serious heart, respiratory, liver, or renal failure
dysfunction of the vocal cord on the opposite side
Trial population
patients with papillary thyroid carcinoma who refuse surgery or active surveillance and choose thermal ablation
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
ultrasound-guided thermal ablation
Procedure/Surgeryultrasound-guided thermal ablation to treat tumor
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
rate of disease progression
cervical lymph node metastases, recurrent tumors and persistent tumors confirmed by pathology
Time frame
through study completion, an average of 6 monthsSecondary outcomes
1
Rate of complications
complications of ablation
Time frame
1 week2
Rate of tumor disappearance
complete disappearance of ablated tumor on ultrasound and contrast-enhanced ultrasound
Time frame
through study completion, an average of 6 months3
Rate of volume reduction
volume reduction of tumor after ablation on ultrasound and contrast-enhanced ultrasound
Time frame
through study completion, an average of 6 months4
rate of change of thyroid function
thyroid function test, including free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroid peroxidase antibody and anti-thyroglobulin antibodies
Time frame
through study completion, an average of 6 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov