Health TrialsbyHealthPanel

Understanding Motivation in Parkinson's Patients Through Neurophysiology

ConditionsParkinson DiseaseDeep Brain StimulationMotivation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco

About this trial

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Has Parkinson's Disease or Dystonia

Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN

Has DBS device implanted either bilaterally or unilaterally

Male or female

Disqualifiers

Severe cognitive impairments

Has MOCA score below 20

Pregnancy

Age less than 18 years old

Trial design

Design model

Crossover

Treatments tested in this trial

  • Stimulation on

    Other intervention

    Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.

  • Stimulation off

    Other intervention

    Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.

  • Decision Making Task

    Behavioral

    Patients will be playing a decision making task through a computer-based application.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: StimulationExperimental treatment 2 interventions
Group B: No StimulationExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease Patients

Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

Time frame
The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years
2

Percent of Risky Decisions made with Percept DBS stimulation off for Parkinson's Disease Patients

Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

Time frame
The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years
3

Reaction Time During Decision-Making Task

The investigators will measure the time it takes for patients to make each decision on the value-based decision-making task in the clinic.

Time frame
The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.
4

Task Success Rate

The investigators will calculate the percentage of trials in which patients complete the task successfully according to predefined task performance criteria.

Time frame
The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Secondary outcomes

1

Interaction Between Neural Low Frequency Power in the LFP with Reaction Time (seconds)

We will assess the effect of reaction time on low frequency power in the LFP data (theta, alpha, beta power) recorded from the Percept device with statistical modeling.

Time frame
Analysis will occur continuously throughout the study period (up to three years) based on collected behavioral and neural data.
2

Interaction Between Neural Low Frequency Power in the LFP with Success Rate (percentage)

We will assess the effect of success rate on low frequency power in the LFP data (theta, alpha, beta power) recorded from the Percept device with statistical modeling.

Time frame
Analysis will occur continuously throughout the study period (up to three years) based on collected behavioral and neural data.
3

Interaction Between Neural Low Frequency Power in the LFP with Force Exerted (arbitrary units)

We will assess the effect of force exerted on low frequency power in the LFP data (theta, alpha, beta power) recorded from the Percept device with statistical modeling.

Time frame
Analysis will occur continuously throughout the study period (up to three years) based on collected behavioral and neural data.
4

Interaction Between Neural Low Frequency Power in the EEG with Reaction Time (seconds)

We will assess the effect of reaction time on low frequency power in the EEG data (theta, alpha, beta power) recorded from the Percept device with statistical modeling.

Time frame
Analysis will occur continuously throughout the study period (up to three years) based on collected behavioral and neural data.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of California, San Francisco

Lead sponsor

Yale University

Collaborator

Rune Labs

Collaborator

University of Birmingham

Collaborator

Source ClinicalTrials.gov
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