Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage
ConditionMiscarriage
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorAswan University
About this trial
Abortion is one of the most common complications of pregnancy. Missed abortion is a type of abortions, occurs in 15%-20% of clinically diagnosed pregnancies and is defined as the retention of pregnancy products in the uterus for several days or weeks after death of the fetus.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Missed or anembryonic pregnancy.
Gestational age from 4 weeks to 26 weeks of pregnancy (confirmed by ultrasound scanning on first day of admittance).
Hemoglobin level more than 9g/l.
Closed cervix.
Disqualifiers
Previous attempt to terminate the pregnancy.
Molar pregnancy
Abnormal uterine lesions such as fibroids or congenital mal formations.
Pregnancy despite of intrauterine contraceptive device.
Trial design
Design model
Parallel
Treatments tested in this trial
Letrozole 2.5mg
Drugto determine the effect of Letrozole as a premedication before misoprostol treatment used to induce missed miscarriage.
Treatment groups
70 Participants
are divided into 2 treatment groupsGroup A: Group A: letrozole and MisoprostolActive comparator 1 intervention
Group B: Group B: MisoprostolActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Miscarriage Achievement
The induction-to-abortion interval in each group
Time frame
10 daysSponsors and contacts
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Source ClinicalTrials.gov