The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.
The main questions it aims to answer are:
1. Which is the proportion of patients who exceed 17 J/min of mechanical power (MP) during the first 72 hours of mechanical ventilation? 2. Is there a difference in terms of cytokine concentration in patients undergoing mechanical power \>17 J/min compared to \<17 J/min?
Patients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP \<17 J/min) and high MP group (average MP ≥17 J/min). The researchers will collect blood and BAL samples and perform cytokine assays.
Patients with AHRF (P/F <300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms
Invasive mechanical ventilation for less than 6 hours
Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)
Age ≥18 years
Prior invasive mechanical ventilation during the same hospitalization
Tracheostomy
Severe anemia (Hb<7g/dL)
Severe neutropenia
Patients with AHRF undergoing mechanical ventilation
Cohort
Prospective
Mechanical ventilation
DeviceMechanical ventilatiom
Patients who exceed 17 J/min of MP
Proportion of patients with AHRF undergoing mechanical ventilation who exceed 17 J/min of MP
Inflammatory cytokines
Difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.
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