Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMayo Clinic
About this trial
This study investigates the role of intraoperative shear wave elastography ultrasound (ISWEU) in identifying healthy brain and tumor tissue stiffness differences. This data may be used to guide tumor resection in future patients.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients must be at least 18 years old.
Patients must have planned surgery for resection of a newly diagnosed or recurrent brain tumors.
Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications.
Patients must have a Karnofsky performance status ≥ 60%.
Disqualifiers
Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk.
Patients with a history of any brain infections.
Patients with implanted devices.
Patients with any other neurological/neurosurgical disease that could affect tissue stiffness.
Trial population
Adults \>= 18 years with a brain tumor diagnosis that will undergo brain surgery with tissue resection as standard of care.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Non-Interventional Study
Other interventionNon-interventional study
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Observational1 intervention
Trial outcomes
Primary outcomes
1
Feasibility of utilizing Intraoperative Shear Wave Elastography Ultrasound (ISWEU) measurements intraoperatively and in the human brain to measure tissue stiffness.
After intraoperative measurement of brain stiffness using ISWEU, analysis will be conducted after each procedure by determining the tissue stiffness from different areas (tumor core, peritumoral brain zone, and non-cancerous brain tissue) and comparing the tumor stiffness between patients. Reviewers will determine whether ISWEU is feasible to be used as a tool to influence surgical decision.
Time frame
At baselineSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: