Use of the Aortic Time-velocity Integral Via Suprasternal Ultrasound to Search Preload Dependence in Paediatric Surgery : Kid's Fluid Management (FM)

ConditionHemodynamic
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0-18
SponsorUniversity Hospital, Lille

About this trial

After major surgery, fluid overload is associated with an increase of morbidity and mortality.

Fluid administration should therefore be given wisely. However, there is a paucity of monitor to predict preload dependence in paediatric anaesthesia.

The aim of this study is to determine if VTI variation, measured through the suprasternal window, with a cardiac doppler probe, can predict preload dependence.

Indeed, cardiac probe are present in most operating room and suprasternal window is reachable in most surgical case, which should allow VTI monitoring for the vast majority of our patient.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patient under 18 admitted to paediatric operating room for a surgical intervention, an endoscopy, an interventional radiology procedure or an imagery and needing a general anaesthesia.

Disqualifiers

Condition preventing a suprasternal ultrasound (tracheostomy, spinal immobilization, suprasternal bandage)

Pathology disturbing respiratory variation of left ventricular stroke volume (PAH, constrictive pericarditis, pericardial effusion, right ventricular dysfunction, complex congenital heart disease, aortic coarctation, patent ductus arteriosus

Every medical condition where Berry's rule of fasting compensation could be unsafe (anuric kidney failure, oedema, heart failure with reduce left ventricular ejection fraction, patient under vasoactive drugs

Opposition to the participation in the study

Trial population

Patient under 18 admitted to paediatric operating room for a surgical intervention, an endoscopy, an interventional radiology procedure or an imagery and needing a general anaesthesia

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Measurement of aortic Vmax and VTI with suprasternal doppler.

    Diagnostic test

    Measurement of aortic Vmax and VTI with suprasternal doppler. Measurement of VTI variation and cardiac output after general anaesthesia. After preoperative fasting compensation, measurement of cardiac output (CO). Search of a difference in the suprasternale VTI variability between the patients who have increased their CO after fasting compensation and the patient who haven't.

Treatment groups

90 Participants
are divided into 1 treatment group
Group A: Measurement of VTI variation and cardiac output after general anaesthesia.1 intervention

Trial outcomes

Primary outcomes

1

Aortic VTI variation (%) measured by suprasternal doppler in percent of mean aortic VTI.

Time frame
During preoperative, after induction and fasting compensation, before incision.

Secondary outcomes

1

Proportion of patient (%) in whom we can use suprasternal aortic measurements.

Time frame
During preoperative period, after induction and fasting compensation, before incision.
2

Optimal threshold of aortic VTI variation (%) measured by suprasternal doppler to determine wether the patient is preload dependant or independent as defined above.

Optimal threshold of aortic VTI variation (%) measured by suprasternal doppler to determine wether the patient is preload dependant or independent as defined above (more than 10% increase of cardiac output measured by transthoracic ultrasound after a 10mL/kg perfusion of cristalloids OR not).

Time frame
During preoperative period, after induction and fasting compensation, before incision.
3

Correlation between : - fasting duration in hours, determined by patient or parent interrogation. - preload dependence as defined above. More than one outcome measure appears to be described.

Correlation between : * fasting duration in hours, determined by patient or parent interrogation. * preload dependence as defined above (increase of 10% or more of stroke volume measured by transthoracic ultrasound after a 10mL/kg perfusion of cristalloids). More than one outcome measure appears to be described.

Time frame
During preoperative period, after induction and fasting compensation, before incision.

Other outcomes

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