Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco

About this trial

The overarching goal of this proposal is to integrate patient social risk information into an existing electronic health record (EHR)-based clinical decision support (CDS) tool (CDSv1) to facilitate emergency department (ED)-initiated, social risk-informed opioid use disorder (OUD) medication treatment and ultimately improve treatment adherence and follow up. The investigators will evaluate the feasibility and acceptability of the social care-enhanced CDS tool, CDSv2, (compared to CDSv1) at a single study site (UCSF) as an intervention to increase medication treatment adherence and follow up for adult ED patients experiencing opioid use disorder using a mixed-methods, before-after approach.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All University of California, San Francisco ED providers (residents, attendings, advanced practice providers) who have used either CDSv1 or CDSv2 will be eligible to participate in surveys and interviews regarding feasibility and acceptability.

English-speaking patients ≥18 years of age presenting to the UCSF ED with opioid use disorder who receive medication treatment (as a result of CDSv1 or CDSv2) will be eligible to participate.

Disqualifiers

they have a medical or psychiatric condition requiring hospitalization at the index ED visit,

are actively suicidal, are cognitively impaired,

present from an extended care facility, or

require opioids for a pain condition.

Trial design

Design model

Sequential

Treatments tested in this trial

  • ED-Based Clinical Decision Support for Opioid Use Disorder

    Other intervention

    The original clinical decision support (CDS) tool, EMergency department initiated BuprenorphinE for opioid use Disorder or EMBED, was designed by researchers at Yale to support emergency department (ED) clinicians with varying levels of experience prescribing buprenorphine for patients with opioid use disorder (OUD). The tool alerts ED providers of a patient who is potentially eligible for MOUD using Epic's storyboard. The provider must then click on the notification to open the OUD evaluation tool, which has multiple components: OUD assessment, OUD diagnosis, withdrawal assessment, and readiness for treatment. These components are then paired with an orderset, "ED Opioid Use Disorder Treatment" that includes nursing orders, prescriptions for buprenorphine and ancillary medications, and substance use disorder discharge resources.

  • Social Care-Enhanced Clinical Decision Support for Opioid Use Disorder

    Other intervention

    The investigators will use human-centered design to adapt the basic CDS tool to incorporate patient social needs, involving patients, staff, and end-user ED clinicians in the iterative design process. This tool is being actively developed.

Treatment groups

300 Participants
are divided into 2 treatment groups
Group A: ED-Based Clinical Decision Support for Opioid Use DisorderActive comparator 1 intervention
Group B: Social Care-Enhanced Clinical Decision Support for Opioid Use DisorderExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

CDSv1 clinician launch

Percentage of ED clinicians who launch CDSv1 for patients with OUD

Time frame
12 months
2

CDSv1 encounter launch

Percentage of eligible encounters (i.e., encounters including patients with OUD as defined by the EHR-derived phenotype) where CDSv1 was launched by clinician

Time frame
12 months
3

CDSv2 clinician launch

Percentage of ED clinicians who launch CDSv2 for patients with OUD

Time frame
12 months
4

CDSv2 encounter launch

Percentage of eligible encounters (i.e., encounters including patients with OUD as defined by the EHR-derived phenotype) where CDSv2 was launched by clinician

Time frame
12 months

Secondary outcomes

1

CDSv1 treatment adherence

Proportion of participants adherent to the same OUD medication prescribed using CDSv1 at 30 days post-ED visit

Time frame
13 months
2

CDSv1 follow up

Proportion of participants receiving formal inpatient, outpatient, or ED-based addiction treatment services at 30 days post-ED visit for CDSv1

Time frame
13 months
3

CDSv2 treatment adherence

Proportion of participants adherent to the same OUD medication prescribed using CDSv2 at 30 days post-ED visit

Time frame
13 months
4

CDSv2 follow up

Proportion of participants receiving formal inpatient, outpatient, or ED-based addiction treatment services at 30 days post-ED visit for CDSv2

Time frame
13 months

Other outcomes

Sponsors and contacts

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University of California, San Francisco

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator