The goal of this observational study is to learn if two specific heart electrical signal patterns can help in detecting the risk of dangerous heart rhythms in athletes, and to see if exercise-based tests can be used instead of invasive hospital procedures to record this electrical signals.
The main questions it aims to answer are:
1. Can special ECG action potential duration markers (R2I2 and PERS) identify athletes who are at higher risk of sudden heart rhythm problems. 2. Can an exercise test give the same information as a non-invasive electrophysiology study.
Researchers will compare athletes who have an implanted heart device (ICD) with athletes who do not, to see if there are differences in these heart signals.
Participants will undergo:
1. ECG recordings during rest and exercise. 2. If they have an ICD or pacemaker, an ECG will be recorded during a non invasive stimulation. 3. A continuous 24 hour ECG.
Age 18 and over.
Participates in regular physical activity for at least 3 hours or greater weekly.
Having Implantable cardioverter defibrillator insitu (cases).
Having a cardiac pacemaker (control).
Pregnancy, as detected by positive urine pregnancy test result.
Inability to comply with study protocols.
Any iatrogenic cardiac pathology (stents, CABG etc).
Unstable ventricular tachycardia (>30 seconds).
Study population will be from a single tertiary care hospital (University Hospitals Leicester), and residents of United Kingdom
Case-control
Prospective
Not listed
Change in Restitution Markers as Determined by R2I2 and PERS
Non-invasive exercise-based tests correlate with electrophysiology study.
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