Using Nicotine to Reverse Age-related Auditory Processing Deficits
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorUniversity of California, Irvine
About this trial
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
Eligibility criteria
Qualifiers
between 18 and 85 years of age
non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency
cognitive performance within two standard deviations of the CERAD mean
Disqualifiers
less than 18 or greater than 85 years of age
deafness or excessive hearing loss
smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
history of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
Trial design
Treatments tested in this trial
- Nicotine gum
- Placebo gum
Treatment groups
48 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, Irvine
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov