Using Strength Tests to Better Understand How Pancreatic Cancer Affects Muscle Mass and Quality of Life
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorBritish Columbia Cancer Agency
About this trial
The goal of this clinical trial is to measure hand grip strength in adults with pancreatic ductal adenocarcinoma (PDAC). The main questions it aims to answer are:
* Is it feasible to measure hand grip strength as part of a clinic visit? * Are changes in hand grip strength related to changes in body composition? * Is hand grip strength related to a person's well-being? * Is hand grip strength related to how a tumour responds to treatment?
Participants will squeeze a device with their hand to measure their hand grip strength and complete questionnaires about their well-being when they are seen in clinic for their regular medical care for PDAC.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older.
Histological and/or radiological diagnosis of resectable, non-resectable, or metastatic PDAC. For resectable PDAC, adjuvant setting only.
ECOG performance status 0-2.
Life expectancy greater than 6 months as judged by the investigator.
Disqualifiers
Individuals with CT imaging performed outside of Vancouver, BC, Canada.
Individuals who are unfit to undergo CT imaging of the third lumbar vertebra (L3).
Individuals who are currently participating in a structured moderate intensity resistance training program.
Individuals who are otherwise judged by the investigator to be unfit to proceed with this protocol.
Trial design
Design model
Single group
Treatments tested in this trial
Hand grip strength assessments using a dynamometer
DeviceSqueeze a dynamometer with one hand to measure hand grip strength.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: Main Study ArmExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Frequency of Participants with Hand Grip Strength (HGS) Measurements at 6 Months From Treatment Start Date
The percentage of participants with hand grip strength (HGS) test results at 6 months from treatment start date. Hand grip strength is measured in kilograms with a hand-held dynamometer.
Time frame
From the date anti-cancer therapy is initiated until the 6-month follow-up assessment.Secondary outcomes
1
Frequency of Participants with Hand Grip Strength (HGS) Measurements at Study Baseline
The percentage of participants with hand grip strength (HGS) test results at study baseline. Hand grip strength is measured in kilograms with a hand-held dynamometer.
Time frame
At the time of the baseline assessment for the study.2
Frequency of Participants with Hand Grip Strength (HGS) Measurements at 3 Months From Treatment Start Date
The percentage of participants with hand grip strength (HGS) test results at 3 months from treatment start date. Hand grip strength is measured in kilograms with a hand-held dynamometer.
Time frame
From the date anti-cancer therapy is initiated until the 3-month follow-up assessment.3
Frequency of Participants with Hand Grip Strength (HGS) Measurements at 9 Months From Treatment Start Date
The percentage of participants with hand grip strength (HGS) test results at 9 months from treatment start date. Hand grip strength is measured in kilograms with a hand-held dynamometer.
Time frame
From the date anti-cancer therapy is initiated until the 9-month follow-up assessment.4
Frequency of Participants with Hand Grip Strength (HGS) Measurements at 12 Months From Treatment Start Date
The percentage of participants with hand grip strength (HGS) test results at 12 months from treatment start date. Hand grip strength is measured in kilograms with a hand-held dynamometer.
Time frame
From the date anti-cancer therapy is initiated until the 12-month follow-up assessment.Sponsors and contacts
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Source ClinicalTrials.gov