Evaluate the protein expression of lactate dehydrogenase enzyme (LDHA) and MCT-1/-4 transporters, involved in lactate synthesis and transport, in prostate carcinoma tissues from severely overweight/obese (BMI \> 27.5) and non-severely overweight/normoweight (BMI \< 27.5) patients affected by prostate carcinoma.
ii. Characterize the immune infiltrate in the prostate carcinoma of the aforementioned patients.
iii. Assess the association between intra-tumoral lactate accumulation (using LDHA and MCT-4 protein expression levels as readouts) and alterations in the tumor immune microenvironment and/or deregulation of relevant oncogenic pathways.
affected by prostate cancer
None
patients affected bt prostate cancer both obese or not obese
Case-control
Retrospective
observational study
Other interventionobservational study
Assess the protein expression of LDHA enzyme and MCT-1/-4 transporters in prostate carcinoma
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Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Lead sponsor
National Research Council
Collaborator
