Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
Utilization of CBC-Derived Inflammatory Indices in Assessing Severity and Prognosis of Acute Pancreatitis.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
adult patients aged 18 years old or older.
patients with acute pancreatitis who were treated in our hospital from January 2019 to March 2025.
Disqualifiers
history of chronic kidney disease
Pregnancy.
History of neoplasm
present of acute infection
Trial population
patients with AP who were treated in our hospital (Al Rhaghe hospital) from January 2019 to March 2025 (age ≥18 years old; written consent will be obtained); also, we prospectively will analyse data of patients with AP who will be admitted within one year
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
CBC derived inflammatory indices
Other interventionComplete blood count, CBC\_based inflammatory indices: 1. Prognostic nutritional index (PNI): PNI is a score based on serum albumin and lymphocyte count, used to assess nutritional and immune status. 2. Systemic inflammation response index (SIRI) : SIRI is an inflammatory marker used to assess systemic inflammation and predict prognosis in various diseases, including cancer and acute conditions. 3. Systemic immune inflammation index (SII) : SII is a composite marker reflecting the balance between host immune and inflammatory status. It is widely used as a prognostic indicator in cancers, cardiovascular disease, and acute inflammatory conditions. 4. platelet lymphcyte ratio (PLR) : (PLR) reflects the balance between thrombosis/inflammation (platelets) and immune regulation (lymphocytes). 5. Neutrophile to lymphcyte ratio (NLR) : (NLR) is a widely used inflammatory marker derived from CBC, indicating systemic inflammation and immune response.
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Correlation between Prognostic Nutritional Index (PNI) and Clinical Severity of Acute Pancreatitis
PNI will be calculated as: PNI = 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count (/mm³). The correlation between PNI (numeric value) and the clinical severity of acute pancreatitis (based on the Revised Atlanta Classification) will be assessed
Time frame
Between 48 and 72 hours after hospital admission2
Correlation between Systemic Immune-Inflammation Index (SII) and Clinical Severity of Acute Pancreatitis
SII will be calculated as: SII = (Platelet count × Neutrophil count) / Lymphocyte count. The correlation between SII (numeric value) and clinical severity will be assessed.
Time frame
Between 48 and 72 hours after hospital admission3
Correlation between Systemic Inflammation Response Index (SIRI) and Clinical Severity of Acute Pancreatitis
SIRI will be calculated as: SIRI = (Neutrophil count × Monocyte count) / Lymphocyte count. The correlation between SIRI (numeric value) and clinical severity will be assessed.
Time frame
Between 48 and 72 hours after hospital admission4
Correlation between Platelet-to-Lymphocyte Ratio (PLR) and Clinical Severity of Acute Pancreatitis
PLR will be calculated as: PLR = Platelet count / Lymphocyte count. The correlation between PLR (numeric ratio) and clinical severity will be assessed.
Time frame
Between 48 and 72 hours after hospital admissionLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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