Utilization of Musculoskeletal Ultrasound to Detect Subclinical Findings in IBD Patients

ConditionsIBD (Inflammatory Bowel Disease)Musculoskeletal Ultrasound

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorAssiut University

About this trial

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, frequently presents with musculoskeletal extraintestinal manifestations (EIMs), such as arthritis and enthesitis, affecting up to 50% of patients. These can be subclinical and are often underestimated by physical examination alone. Musculoskeletal ultrasound (MSK-US) is a sensitive, non-invasive tool for detecting both clinical and subclinical inflammation. Despite its benefits, there is no standardized MSK-US protocol specifically for IBD patients. This study aims to develop a structured MSK-US assessment protocol, evaluate its effectiveness in detecting musculoskeletal involvement, and investigate its relationship with IBD disease activity.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patients diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis)

Patients without a definite diagnosis of inflammatory arthritis, to focus on subclinical musculoskeletal involvement.

Disqualifiers

Patients with a prior clinical diagnosis of inflammatory arthritis or other rheumatologic diseases.

Patients with complicated or severe comorbidities that may interfere with musculoskeletal evaluation or study participation (e.g., severe infections, malignancies).

Trial population

The study population will consist of patients 18 years old or older confirmed diagnosis with IBD attending gastroenterology or IBD specialty clinics. Participants may be either symptomatic or asymptomatic for musculoskeletal complaints, allowing for the detection of both clinical and subclinical inflammatory findings.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

MSK Ultrasound with Doppler on joints, muscles & tendons
Radiation
Musculoskeletal Ultrasound (MSK-US) is a non-invasive, real-time, and sensitive imaging modality that can detect synovial hypertrophy, joint effusion, enthesitis, tenosynovitis, bursitis, and power Doppler (PD) signal indicative of active inflammation. Unlike standard clinical assessment, which may miss subclinical inflammation.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

the prevalence of subclinical musculoskeletal abnormalities

The prevalence will be reported as a percentage of patients with inflammatory bowel disease (IBD) who have no clinical history of inflammatory arthritis, who are found to have subclinical musculoskeletal abnormalities detected by ultrasound.

Time frame

baseline.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: