Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University

About this trial

This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases. The study will check how well the LSI can tell apart different lung diseases (like pneumothorax, interstitial lung disease, COPD, pneumonia, and pulmonary edema), how it relates to signs of disease severity, and how consistent the results are between different operators who have received the same training. Secondary objectives include assessing patient and operator satisfaction and feasibility using validated Likert scales.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age 18 years and older.

Diagnosed with one of the specified pulmonary diseases, or a healthy control

Able to provide written informed consent

Disqualifiers

Inability to tolerate or undergo a lung ultrasound

Extensive chest wall pathology precluding assessment

Unscorable >2 zones per protocol

Withdrawal of consent

Trial population

Adult patients (\>18 years) with: * Pneumothorax * Interstitial lung disease (ILD/IPF) * COPD/emphysema * Bronchiectasis * Community-acquired pneumonia * Pulmonary edema * Pleural effusion * Healthy controls

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Lung Ultrasound

    Diagnostic test

    All enrolled patient will be subjected to Lung Ultrasound examination LUS

Treatment groups

700 Participants
are divided into 8 treatment groups

8

Treatment groups

See each treatment group below.

Group A: Chronic obstructive pulmonary disease (COPD)1 intervention
Group B: Pneumothorax1 intervention
Group C: Community-acquired pneumonia (CAP)1 intervention
Group D: Interstitial lung diseases (ILDs)1 intervention
Group E: Bronchiectasis1 intervention
Group F: Pleural Effusion1 intervention
Group G: Pulmonary Oedema1 intervention
Group H: Control1 intervention

Trial outcomes

Primary outcomes

1

Discriminative performance of LSI (total score, 0-36) between disease groups

The primary outcome is establishing a pattern of LSI among the seven studied groups

Time frame
At Baseline

Secondary outcomes

1

Correlation of LSI with clinical severity indices

Correlation of LSI with clinical severity indices (PaO₂/FiO₂ ratio, FVC %, mMRC, 6MWT)

Time frame
At Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Aliae AR Mohamed Hussein [ahussein

Collaborator