This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The primary objective is to determine the validity of a self-assessment tool in encouraging undiagnosed participants, recruited through a social media campaign, to seek medical evaluation for suspected myasthenia gravis (MG).
Reside within the 50 states of the United States at the time of enrollment
Age 19 or older if reside in Nebraska or Alabama, Age 21 or older if reside in Mississippi, Age 18 years or older if reside in any other state
Active email account
Fluency in English (spoken / written), as demonstrated by the ability to read and sign the Informed Consent Form
Live in an overseas territory of the United States
Inability or unwillingness to provide written informed consent
Diagnosed myasthenia gravis, including sero-negative MG*
Diagnosed multiple sclerosis
Adult participants who have undiagnosed neuromuscular symptoms
Cohort
Prospective
Social media recruitment
BehavioralSocial media users exposed to a variety of paid social media advertisements as a recruitment tool for study enrollment
Self-Assessment
BehavioralEligible participants are asked to complete self-administered physical tests to assess inducible fatigue of specific muscle groups
Follow-up
BehavioralPatients triaged based on their assessed risk of MG are asked to complete recommended follow-up with a clinician to determine presence of myasthenia gravis
Self-Assessment tool validity
Measure the specificity and sensitivity of the Self-Assessment tool
Social media engagement
Measure the engagement and cost metrics of the social media ad campaign
Time to diagnosis
Evaluate the time to diagnosis for any participant who has a new diagnosis of MG after completing the study
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