Two cross-sectional, repeated-pass, community-based studies will be carried out during the school year. The first study will be conducted from November to December. This period corresponds to the end of the rainy season and the end of the mango season, which is one of the main sources of vitamin A in the Orodara region.
The second survey will be carried out 5 to 6 months (April-May of the following year) after data collection for the first study, corresponding to the mango season. The same schoolchildren recruited during the first phase of data collection (5 to 6 months earlier) will be the participants in the second study. The interest of this study is to use nuclear techniques to implement a strategy for the precise and accurate determination of Vitamin A status in order to reinforce existing Vitamin A interventions and policies.
School children aged 7-12 years
Child's guardian or parent is willing to provide informed consent
Child's family plans to remain resident in the study areas during the study period
Clinical evidence of vitamin A deficiency a mis en forme : Anglais (Royaume-Uni)a mis en forme : Anglais (États-Unis)a mis en forme : Anglais (États-Unis)a mis en forme : Anglais (États-Unis)
Severe malnutrition (weight-for age Z score (WAZ) or height-for-age Z score (HAZ) <-3 SD)
Serious illnesses including tuberculosis, symptomatic HIV infection
Child aged <6 years or >12 years
The proposed study will be carried out in a primary school in the Western part of Burkina Faso, in Orodara, a village at the outer edge of Bobo Dioulasso, where we will target children aged 7 to 12 years. Most inhabitants of the village are middle-income farmers and their families.
Cohort
Cross-sectional
Retinol isotope dilution technique
Diagnostic testA group of 60 school children will be recruited through a stratified sampling. To this first group of 60 school children a retinol isotope dilution (RID) test for total body store assessment will be applied. The remaining 98 school children will be recruited according to stratified sampling and divided into two groups of 49 children (females and males). To these groups of children, the modified relative dose response (MRDR) test, a qualitative measure of vitamin A status will be used to investigate the absorption of 3,4-didehydroretinyl acetate in oil.
Vitamin A status
Blood vitamin A concentration and liver Vitamin A reserves
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Institut de Recherche en Sciences de la Sante, Burkina Faso
Lead sponsor
International Atomic Energy Agency (IAEA)
Collaborator