Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.

ConditionSepsis

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorUniversity Hospital Center of Martinique

About this trial

This study aims to validate a simple and reproducible index of capillary leak (CLI) in septic shock, based on haemoglobin (Hb) variation induced by standardised fluid resuscitation. To achieve this, the correlation between CLI and biomarkers of endothelial dysfunction-angiopoietin-2 and syndecan-1-will be assessed in both septic and non-septic shock patients. CLI may contribute to the individualisation of fluid management in patients with septic shock.

Eligibility criteria

Qualifiers

Adults admitted to the general ICU within 24 hours with a diagnosis of septic shock

Eligible for blood sampling during daytime hours

Adults admitted to the postoperative ICU within 24 hours after surgery

Need for fluid resuscitation

Disqualifiers

- Clarkson's disease (idiopathic capillary leak syndrome)

Pre-existing extracellular fluid overload (e.g., cirrhosis, decompensated heart failure, nephrotic syndrome, chronic kidney disease on or awaiting dialysis)

Active bleeding or hemolysis

Receiving ECMO

Trial design

Treatments tested in this trial

TEST GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in septic shock patients.
CONTROL GROUP: A standardised fluid bolus of 8 mL/kg of ideal body weight using Ringer's lactate will be administered in non-septic postoperative patients.

Treatment groups

100 Participants

are divided into 2 treatment groups

Sponsors and collaborators

University Hospital Center of Martinique

Lead sponsor

Source ClinicalTrials.gov