Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorCentre Hospitalier Universitaire de Saint Etienne

About this trial

In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual supports to optimize memory. By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images. The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Enrollment in a social security program

Age 60 or older

French as a native language

Consent to participate

Disqualifiers

Uncorrected visual or hearing impairments

Language or motor impairments

Delirium or psychosis.

Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition).

Trial design

Design model

Crossover

Treatments tested in this trial

  • Control condition

    Behavioral

    Reading a sentence aloud and the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.

  • Motor mental imagery

    Behavioral

    Following the reading of each sentence, the participant is instructed to mentally simulate performing the action described in the sentence. And the participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.

  • Action execution

    Behavioral

    After reading the sentence, the participant pantomimes the action described and The participant is asked to freely recall, without delay and without cues, all the sentences presented in the block. The number of correctly recalled sentences is recorded.

Treatment groups

80 Participants
are divided into 3 treatment groups
Group A: Control conditionExperimental treatment 1 intervention
Group B: Motor imagery interventionExperimental treatment 1 intervention
Group C: Real actionExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Free recall score

The free recall score corresponds to the number of sentences spontaneously retrieved by participants after learning, measuring free retrieval ability.

Time frame
at 1 week

Secondary outcomes

Other outcomes

Sponsors and contacts

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