Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.
Patients with liver cirrhosis;
Patients with acute gastrointestinal bleeding presenting with hematemesis, melena, and/or hematochezia;
Adults (age≥18 years old).
Components of Child-Pugh, MELD, and CAGIB scores are not available;
In-hospital outcomes are not evaluable.
Patients with liver cirrhosis and acute gastrointestinal bleeding
Other
Prospective
Not listed
Mortality
Death caused by any events during hospitalizations.
Failure to control bleeding within 5 days
Failure is defined as death or need to change therapy defined by one of the following criteria within 5 days: 1) Fresh hematemesis or nasogastric aspiration of ≥100 ml of fresh blood ≥2 h after the start of a specific drug treatment or therapeutic endoscopy; 2) Development of hypovolaemic shock; 3) 3g drop in hemoglobin (9% drop of hematocrit) within any 24 hours period if no transfusion is administered.
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Xingshun Qi
Lead sponsor
General Hospital of Shenyang Military Region
Sponsor institution
