About this trial
Doctors use patterns on heart rhythm tracings (ECGs) to predict where abnormal heart rhythms originate, but these prediction methods were developed in people with normal heart structure. Patients with repaired Tetralogy of Fallot have hearts that developed differently, and cardiologists do not know if these prediction methods work accurately for them. In this study, the investigators will test whether three commonly used prediction methods work in Tetralogy of Fallot patients by pacing the heart from known locations during an already-scheduled heart procedure and comparing the predicted location to the actual location. Participation adds approximately 15 minutes to the procedure and does not require additional visits. The results will help cardiologists understand whether current methods can be trusted when planning treatments for abnormal heart rhythms in this patient population, or whether new prediction methods need to be developed.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients >/= 18 years with repaired tetralogy of Fallot with pulmonary stenosis scheduled for clinically-indicated diagnostic electrophysiology (EP) study.
Disqualifiers
Dextrocardia or mesocardia.
Double outlet right ventricle.
Tetralogy of Fallot with pulmonary atresia.
Contraindication to femoral arterial access.
Trial design
Single group
Treatments tested in this trial
RV and LV pace mapping
Diagnostic testPace mapping at systematic RV and LV sites according to select published VT/PVC localization schema will be performed in study patients.
Treatment groups
Trial outcomes
Primary outcomes
Algorithm accuracy (%)
The proportion of correctly identified pace sites among all evaluable pace sites, and analyzed separately for each algorithm according to its intended classification scheme. Concordance at each pace site will be assessed as a binary outcome.
Locations
Sponsors and contacts
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