Health TrialsbyHealthPanel

Validation of NAD+ Measurements for Human Clinical Studies

ConditionHealthy Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-110
SponsorUniversity of Pennsylvania

About this trial

The purpose of this study is to determine nicotinamide adenine dinucleotide (NAD) levels in healthy adult subjects before and after supplementing with over-the counter nicotinamide riboside (NR) using magnetic resonance spectroscopy (MRS).

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female age18-35 years or 70 years or older, healthy

if female reproductive potential, use of highly effective contraception (at least 1 month prior to screening and during study participation).

No known sensitivity to NR

No use of niacin, blood thinners or chemotherapy agents

Disqualifiers

None

Trial design

Design model

Single group

Treatments tested in this trial

  • Oral NR Supplementation

    Dietary supplement

    Oral Nicotinamide Riboside (NR)

Treatment groups

48 Participants
are divided into 1 treatment group
Group A: NR ArmExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Nicotinamide adenine dinucleotide (NAD) measurement in brain MRI

NAD level will be assessed in brain MRI

Time frame
Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with nicotinamide riboside (NR)
2

NAD measurement of calf MRI

NAD level in calf MRI

Time frame
Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with nicotinamide riboside (NR)

Secondary outcomes

1

Serum NAD metabolites

Measurement of serum metabolites of Nicotinamide adenine dinucleotide

Time frame
Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with NR
2

Urine NAD metabolites

Measurement of urine NAD metabolites

Time frame
Before supplementation and after 4 weeks (-3 days, +7days) of supplementation with nicotinamide riboside (NR)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Pennsylvania

Lead sponsor

National Institute on Aging (NIA)

Collaborator

Source ClinicalTrials.gov
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