Health TrialsbyHealthPanel

Valuation in Depressed Mood, Anhedonia, and Anxiety

ConditionNeurobehavioral Components of Reward and Loss Valuation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-50
SponsorVirginia Polytechnic Institute and State University

About this trial

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Disqualifiers

history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Trial design

Design model

Parallel

Treatments tested in this trial

  • cognitive behavioral therapy

    Behavioral

    cognitive behavioral therapy

  • valuation with instruction

    Behavioral

    repeat laboratory sessions of computerized learning game

  • valuation without instruction

    Behavioral

    repeat laboratory sessions of computerized learning game

Treatment groups

252 Participants
are divided into 3 treatment groups
Group A: Cognitive behavioral therapyActive comparator 1 intervention
Group B: Valuation with instructionActive comparator 1 intervention
Group C: Valuation without instructionActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

change in proportion correct on the 'N-arm bandit learning task'

change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit

Time frame
study entrance to study exit, an average of 12 weeks

Secondary outcomes

1

change in depression symptoms (Beck Depression Inventory)

change in depression symptoms from study entrance to study exit

Time frame
study entrance to exit, an average of 12 weeks
2

change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)

change in anxiety symptoms from study entrance to study exit

Time frame
study entrance to exit, an average of 12 weeks
3

change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)

change in anhedonia symptoms from study entrance to study exit

Time frame
study entrance to exit, an average of 12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Virginia Polytechnic Institute and State University

Lead sponsor

Source ClinicalTrials.gov
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