Vascular Aging and Acute Kidney Injury After Cardiac Surgery
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNanjing First Hospital, Nanjing Medical University
About this trial
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients aged 18 years or older.
Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
Patients who are able to provide written informed consent.
Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.
Disqualifiers
Patients younger than 18 years.
Patients with preoperative end-stage renal disease or maintenance dialysis.
Patients who are unable to complete the study-specified vascular aging assessment.
Patients who decline participation or withdraw informed consent.
Trial population
The study population will consist of adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Eligible patients will receive perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol. Participants will be followed for postoperative acute kidney injury within 7 days after surgery.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Multidimensional Vascular Aging Assessment
Other interventionPerioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.
Treatment groups
472 Participants
are divided into 1 treatment groupGroup A: Cardiac Surgery Cohort1 intervention
Trial outcomes
Primary outcomes
1
Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery
Postoperative acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria based on postoperative renal function changes. The outcome will be recorded as the occurrence of acute kidney injury during the postoperative 7-day period.
Time frame
From the date of surgery to postoperative day 7Secondary outcomes
1
Severity of Postoperative Acute Kidney Injury
The severity of postoperative acute kidney injury will be classified according to predefined staging criteria during the postoperative 7-day period.
Time frame
From the date of surgery to postoperative day 7Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: