Velocity-Based Resistance Training Effects on Inflammation in Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-75
SponsorNational Taipei University
About this trial
This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Aged 60-75 years or older
No regular resistance training habit (defined as ≥2 sessions per week) in the past year
No musculoskeletal injuries within the past six months
Disqualifiers
Obesity (BMI > 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
Regular use of anti-inflammatory medications (e.g., NSAIDs).
Smoking or alcohol abuse
Inability to safely perform the prescribed resistance exercise movements
Trial design
Design model
Crossover
Treatments tested in this trial
Resistance exercise
Other interventionThe RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.
Treatment groups
60 Participants
are divided into 4 treatment groupsGroup A: low training volume resistance exerciseExperimental treatment 1 intervention
Group B: medium training volume resistance exerciseExperimental treatment 1 intervention
Group C: high training volume resistance exerciseExperimental treatment 1 intervention
Group D: sedentary controlNo intervention 0 interventions
Trial outcomes
Primary outcomes
1
Changes in IL-6 concentration
Plasma IL-6 concentrations will be measured and reported in pg/mL.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining2
Changes in soluble IL-6 receptor concentration
Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining3
Changes in soluble gp130 concentration
Soluble gp130 concentrations will be measured and reported in ng/mL.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining4
Changes in IL-10 concentration
IL-10 concentrations will be measured and reported in pg/mL.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detrainingSecondary outcomes
1
Borgs Ratings of Perceived Exertion (RPE)
Borgs RPE is a method of estimating exertion rating, based on a 1 to 10 rating scale (1 being the no exertion at all, 10 being maximal exertion).
Time frame
1-hour during each exercise intervention2
Handgrip strength
Maximal handgrip strength will be assessed using a digital hand dynamometer and reported in kilograms.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining3
Knee extension strength
Maximal voluntary isometric and isokinetic concentric knee extension strength of the dominant leg will be assessed using an isokinetic dynamometer and reported in Newton-meters.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining4
30-second chair-stand test
Lower-body functional capacity will be assessed by the number of repetitions completed during a 30-second chair-stand test.
Time frame
Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detrainingSponsors and contacts
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Source ClinicalTrials.gov