Ventilatory Parameters in Acute Neurological Injury
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16+
SponsorRamos Mejía Hospital
About this trial
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP) with the baseline neurological status (assessed through the Glasgow coma score) in adults patients under mechanical ventilation with acute neurological injury secondary to stroke, brain trauma or subarachnoid hemorrhage.
The main question\[s\]it aims to answer are:
1. In patients with acute neurological injury under mechanical ventilation, is there a correlation between the acute neurological injury, assessed using the Glasgow scale on admission, and baseline ventilatory parameters? 2. In patients with acute neurological injury under mechanical ventilation, are the baseline ventilatory parameters altered at baseline?
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
All patients ≥ 16 years of age with an ANI requiring mechanical ventilation for neurological causes.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
19 Participants
are grouped into 1 trial groupGroup A: Patients with acute neurological injury
Trial outcomes
Primary outcomes
1
Correlation between acute neurological injury and mechanical power normalized to predicted body weight
To determine the degree of correlation between acute neurological injury, assessed using the Glasgow coma score \[GCS; with a score between 3 (worst score, most severe) and 15 (best score, least severe)\] and mechanical power normalized to predicted body weight (Joules/minute/kilograms)
Time frame
The first 2 days of the patient on mechanical ventilation (MV)Secondary outcomes
1
Correlation between acute neurological injury and mechanical power
To determine the degree of correlation between acute neurological injury, assessed using the Glasgow coma score \[GCS; with a score between 3 (worst score, most severe) and 15 (best score, least severe)\] and mechanical power (Joules/minute)
Time frame
The first 2 days of the patient on mechanical ventilation (MV)2
Correlation between acute neurological injury and ΔP
To determine the degree of correlation between acute neurological injury, assessed using the Glasgow coma score \[GCS; with a score between 3 (worst score, most severe) and 15 (best score, least severe)\] and ΔP (centimeter of water)
Time frame
The first 2 days of the patient on mechanical ventilation (MV)3
To assess static pressure
To assess the static pressure: Pplat (centimeter of water)
Time frame
The first 2 days of the patient on mechanical ventilation (MV)4
To assess the respiratory system resistance
To assess the respiratory system resistance: it is the relationship between the difference between peak pressure and static pressure with the inspiratory flow: R = (Ppeak-Pplat)/Inspiratory flow (centimeter of water/liters/second)
Time frame
The first 2 days of the patient on mechanical ventilation (MV)Locations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Roberto Santa CruzRecruitingB6600KCL, Ciudad Autonoma de Buenos Aires, Buenos Aires
Argentina
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Source ClinicalTrials.gov