About this trial
This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are:
Does having control over pain within specific contexts alter how much pain people feel-even when the stimulus intensity remains constant? How do different types of environments (safe, controllable, or uncontrollable) shape pain-related brain activity, subjective anxiety, and physiological arousal? How do people perform cognitively demanding or distracting tasks (and retain their memory) when under threat versus when in control? Lastly, how do these learned associations with spatial contexts persist or adapt when environmental contingencies are explicitly changed?
Taken together, exploration of these factors may lay the groundwork for understanding how placebo-related mechanisms-including perceived control, contextual learning, emotional engagement, and distraction-interact to shape pain and anxiety in complex environments.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis
No self-reported current chronic pain, or acute pain within three months of the study period
No current migraine disorder (i.e., 15 headache days or more in 1 month)
Disqualifiers
None
Trial design
Single group
Treatments tested in this trial
Pain Threat Manipulation
BehavioralParticipants receive brief thermal pain stimuli in certain virtual environments to examine how threat influences perception and physiological responses.
Pain Controllability Manipulation
BehavioralIn some contexts, participants can reduce or avoid pain using a button; in others, no action changes the outcome. This manipulation is used to study the effects of perceived control over pain.
Treatment groups
Trial outcomes
Primary outcomes
Pain Intensity Ratings
Self-reported pain level following each thermal stimulus, measured on a visual analog scale. 0-100 scale with 0 indicating no pain and higher values indicating more pain.
Self-Reported Anxiety Ratings
Participants rate their current level of anxiety using a 0-100 visual analogue Subjective Units of Distress Scale (SUDS). 0 indicates no anxiety and higher values indicating more anxiety.
Sponsors and contacts
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