About this trial
This randomized controlled trial aims to evaluate the effectiveness of a mobile- and virtual reality-based mindfulness and breathing intervention on stress, burnout, sleep quality, and cognitive function among Rotating-shift nurses. Participants will be randomly assigned to one of four groups: (1) health education control group, (2) mobile-based mindfulness only, (3) mobile-based mindfulness combined with brief structured breathing, and (4) virtual reality-assisted mindfulness combined with brief structured breathing. The intervention will last for 8 weeks, with participants practicing 5 times per week for 10 minutes per session. Primary outcomes include perceived stress, burnout levels, sleep quality, and cognitive function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age between 20 and 65 years.
Able to understand spoken or written Mandarin or Taiwanese.
Employed full-time for at least 3 months with a signed employment contract.
Has worked rotating shifts (including day, evening, and/or night shifts) in the past 3 months.
Disqualifiers
Pregnant or breastfeeding individuals.
History of substance abuse (e.g., tobacco, illicit drugs).
Alcohol consumption ≥350 ml/week with alcohol content ≥3.5%.
Diagnosed or suspected autonomic nervous system disorders.
Trial design
Parallel
Treatments tested in this trial
Health Education Material
Other interventionWeekly electronic health education handbooks covering nutrition, sleep, shift work, stress awareness, and digital device use.
Mobile-Based Mindfulness
BehavioralGuided mindfulness practice via mobile app using pre-recorded 360° natural environment video.
Mobile-Based Mindfulness combined with Breathing
BehavioralMindfulness training combined with brief structured breathing exercises via mobile app using 360° nature video.
VR-Based Mindfulness combined with Breathing
BehavioralVirtual reality-delivered mindfulness and structured breathing training using immersive 360° natural environment video.
Treatment groups
Trial outcomes
Primary outcomes
Chinese version of the 10-item Perceived Stress Scale (PSS-10-C )
This scale assesses how unpredictable, uncontrollable, and overloaded individuals perceive their lives to be. It contains two subscales: perceived helplessness and perceived self-efficacy. Each item is rated on a 5-point Likert scale from 0 (never) to 4 (very often). The scale has demonstrated high internal consistency (Cronbach's α = 0.85) and good test-retest reliability (r = 0.66, p \< 0.001) over three months in Chinese-speaking nursing samples.
Perceived Stress -Safety Culture Subscale.
This measure uses the "Perception of Stress" subscale from the Taiwan version of the Safety Attitudes Questionnaire (SAQ), which includes four items that assess healthcare professionals' awareness of stress and its effects on performance. One item is reverse-coded. Items are rated on a 5-point Likert scale ranging from 1 (strongly disagree) to 5 (strongly agree). Subscale scores are transformed to a 0-100 scale using the formula: Transformed score = (mean score - 1) × 25. Higher scores indicate greater perceived stress. This transformation supports standardization and enables comparison across domains.
Nursing Burnout Scale (NBS)
This scale was developed for clinical nurses and evaluates emotional exhaustion, reduced personal accomplishment, and depersonalization. It includes 12 items across three subscales, with four items per subscale. Each item is rated on a 4-point Likert scale ranging from 1 (strongly disagree) to 4 (strongly agree). The total scale has demonstrated high internal consistency (Cronbach's α = 0.92) and acceptable subscale reliability (Cronbach's α = 0.64-0.86), indicating good psychometric properties for use among nursing professionals.
Secondary outcomes
Actigraphy-Based Sleep Quality Index
A composite sleep quality score derived from multiple actigraphy-based parameters including total sleep time, sleep efficiency, number of awakenings, and sleep onset latency. Each parameter will be normalized and weighted based on validated sleep scoring algorithms (e.g., Sadeh algorithm), and then aggregated into a composite index to represent overall sleep quality. Higher scores indicate better sleep.
Sleep quality. Taiwanese version of the Pittsburgh Sleep Quality Index (PSQI-TC )
This outcome measure uses the Taiwanese version of the Pittsburgh Sleep Quality Index (PSQI-TC) to evaluate participants' sleep quality. The PSQI-TC includes 19 items across seven domains: subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleeping medication, and daytime dysfunction. Each item is scored from 0 to 3, and total scores range from 0 to 21, with higher scores indicating poorer sleep quality. The scale has demonstrated strong internal consistency, with Cronbach's α ranging from 0.83 to 0.85, and is culturally adapted for use among shift-working nurses in Taiwan.
Cognitive Function - Visual Pursuit Test (VTS-LVT)
This test evaluates visual orientation performance and spatial scanning ability under time pressure. The outcome will include accuracy rate and average reaction time (in milliseconds).
Cognitive Function - Determination Test (VTS-DT)
This test assesses reactive stress tolerance and decision-making performance under time constraints. The outcome measures include number of errors and average reaction time (in milliseconds).
Other outcomes
Blood Pressure Monitoring Device - Omron HEM-907XL
This outcome will include measurements of systolic and diastolic blood pressure using the Omron HEM-907XL, a validated automatic digital sphygmomanometer. Blood pressure will be recorded using the three-reading average method while participants are in a seated resting position. Data will be used for subsequent analysis of cardiovascular responses to intervention.
Locations
Sponsors and contacts
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Chang Shih-Chin
Lead sponsor
National Defense Medical Center, Taiwan
Sponsor institution
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